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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P35368
No. Gene UniProt ID Protein Name Pathway PDB
1 ADRA1B P35368 Alpha-1B adrenergic receptor hsa04020; hsa04022; hsa04080; hsa04261; hsa04270; hsa04970 NA


87 known interactions (drugs) of input target (ADRA1B): Alpha-1B adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Illicit		 SmallMoleculeDrug DB01576 Dextroamphetamine Thumb
2 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
3 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
5 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
6 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
7 Approved SmallMoleculeDrug DB01162 Terazosin Thumb
8 Approved;
Illicit		 SmallMoleculeDrug DB01579 Phendimetrazine Thumb
9 Approved SmallMoleculeDrug DB11124 Racepinephrine Thumb
10 Approved SmallMoleculeDrug DB00800 Fenoldopam Thumb
11 Approved;
Investigational		 SmallMoleculeDrug DB00723 Methoxamine Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
13 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB09205 Moxisylyte Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
16 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
17 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb
19 Approved;
Investigational		 SmallMoleculeDrug DB00908 Quinidine Thumb
20 Approved SmallMoleculeDrug DB00692 Phentolamine Thumb
21 Approved SmallMoleculeDrug DB00661 Verapamil Thumb
22 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb
23 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB09128 Brexpiprazole Thumb
26 Approved SmallMoleculeDrug DB08922 Perospirone Thumb
27 Approved SmallMoleculeDrug DB00457 Prazosin Thumb
28 Approved;
Investigational		 SmallMoleculeDrug DB01608 Propericiazine Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb
30 Approved SmallMoleculeDrug DB00211 Midodrine Thumb
31 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
32 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
33 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
34 Approved SmallMoleculeDrug DB00925 Phenoxybenzamine Thumb
35 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
36 Approved;
Investigational		 SmallMoleculeDrug DB01255 Lisdexamfetamine Thumb
37 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
38 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
39 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb
40 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
41 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb
42 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
43 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
44 Approved SmallMoleculeDrug DB06207 Silodosin Thumb
45 Approved;
Withdrawn		 SmallMoleculeDrug DB00679 Thioridazine Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb
47 Approved SmallMoleculeDrug DB01365 Mephentermine Thumb
48 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb
49 Approved SmallMoleculeDrug DB09195 Lorpiprazole Thumb
50 Experimental SmallMoleculeDrug DB09202 Cirazoline Thumb
51 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
52 Approved SmallMoleculeDrug DB00575 Clonidine Thumb
53 Approved;
Investigational		 SmallMoleculeDrug DB00935 Oxymetazoline Thumb
54 Approved SmallMoleculeDrug DB00590 Doxazosin Thumb
55 Approved SmallMoleculeDrug DB00841 Dobutamine Thumb
56 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
57 Approved SmallMoleculeDrug DB00298 Dapiprazole Thumb
58 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
59 Approved SmallMoleculeDrug DB00388 Phenylephrine Thumb
60 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb
61 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
62 Investigational SmallMoleculeDrug DB09204 Arotinolol Thumb
63 Approved;
Vet approved		 SmallMoleculeDrug DB00668 Epinephrine Thumb
64 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
65 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb
66 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
67 Approved;
Investigational		 SmallMoleculeDrug DB00745 Modafinil Thumb
68 Approved;
Investigational		 SmallMoleculeDrug DB06694 Xylometazoline Thumb
69 Approved;
Investigational		 SmallMoleculeDrug DB00346 Alfuzosin Thumb
70 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
71 Experimental SmallMoleculeDrug DB09203 Synephrine Thumb
72 Approved;
Vet approved		 SmallMoleculeDrug DB01614 Acepromazine Thumb
73 Approved SmallMoleculeDrug DB11577 Indigotindisulfonic Acid Thumb
74 Approved;
Investigational		 SmallMoleculeDrug DB00706 Tamsulosin Thumb
75 Approved;
Investigational		 SmallMoleculeDrug DB01136 Carvedilol Thumb
76 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
77 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
78 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb
79 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
80 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
81 Investigational SmallMoleculeDrug DB05469 R450 Thumb
82 Approved SmallMoleculeDrug DB00598 Labetalol Thumb
83 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
84 Approved SmallMoleculeDrug DB11278 DL-Methylephedrine Thumb
85 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
86 Approved;
Investigational		 SmallMoleculeDrug DB06262 Droxidopa Thumb
87 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb


20 predicted interactions (drugs) of input target (ADRA1B): Alpha-1B adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 98.5%
2 Approved SmallMoleculeDrug DB06216 Asenapine Thumb 90.7%
3 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb 90.0%
4 Approved;
Investigational		 SmallMoleculeDrug DB01069 Promethazine Thumb 86.4%
5 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb 85.8%
6 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb 85.7%
7 Approved;
Investigational		 SmallMoleculeDrug DB00656 Trazodone Thumb 85.3%
8 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb 85.2%
9 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00875 Flupentixol Thumb 84.1%
10 Approved SmallMoleculeDrug DB00964 Apraclonidine Thumb 84.0%
11 Experimental;
Illicit		 SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb 83.2%
12 Approved SmallMoleculeDrug DB01295 Bevantolol Thumb 83.2%
13 Approved SmallMoleculeDrug DB00215 Citalopram Thumb 82.7%
14 Approved;
Investigational		 SmallMoleculeDrug DB00831 Trifluoperazine Thumb 82.6%
15 Approved;
Vet approved		 SmallMoleculeDrug DB00797 Tolazoline Thumb 82.3%
16 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb 82.2%
17 Approved;
Investigational		 SmallMoleculeDrug DB01175 Escitalopram Thumb 81.2%
18 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb 81.0%
19 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb 80.0%
20 Approved SmallMoleculeDrug DB00449 Dipivefrin Thumb 79.8%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.