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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9NY46
No. Gene UniProt ID Protein Name Pathway PDB
1 SCN3A Q9NY46 Sodium channel protein type 3 subunit alpha hsa04742 NA


7 known interactions (drugs) of input target (SCN3A): Sodium channel protein type 3 subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB13269 Dichlorobenzyl alcohol Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00909 Zonisamide Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb
4 Investigational SmallMoleculeDrug DB05232 Tetrodotoxin Thumb
5 Approved SmallMoleculeDrug DB06218 Lacosamide Thumb
6 Approved;
Vet approved		 SmallMoleculeDrug DB00252 Phenytoin Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB05541 Brivaracetam Thumb


20 predicted interactions (drugs) of input target (SCN3A): Sodium channel protein type 3 subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb 36.1%
2 Approved;
Vet approved		 SmallMoleculeDrug DB00281 Lidocaine Thumb 36.0%
3 Approved SmallMoleculeDrug DB01438 Phenazopyridine Thumb 32.6%
4 Approved;
Investigational		 SmallMoleculeDrug DB00243 Ranolazine Thumb 32.3%
5 Approved;
Investigational		 SmallMoleculeDrug DB04930 Permethrin Thumb 31.4%
6 Approved SmallMoleculeDrug DB06201 Rufinamide Thumb 28.3%
7 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb 27.1%
8 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 25.7%
9 Approved SmallMoleculeDrug DB01121 Phenacemide Thumb 25.4%
10 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 25.2%
11 Experimental SmallMoleculeDrug DB13520 Metergoline Thumb 24.9%
12 Approved SmallMoleculeDrug DB13154 Parachlorophenol Thumb 24.3%
13 Approved;
Vet approved		 SmallMoleculeDrug DB00527 Cinchocaine Thumb 23.3%
14 Approved;
Withdrawn		 SmallMoleculeDrug DB01195 Flecainide Thumb 22.8%
15 Approved SmallMoleculeDrug DB01595 Nitrazepam Thumb 22.2%
16 Approved;
Investigational		 SmallMoleculeDrug DB01086 Benzocaine Thumb 21.0%
17 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 20.9%
18 Approved;
Withdrawn		 SmallMoleculeDrug DB00473 Hexylcaine Thumb 20.8%
19 Approved;
Investigational		 SmallMoleculeDrug DB00297 Bupivacaine Thumb 20.7%
20 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 19.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.