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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P28482
No. Gene UniProt ID Protein Name Pathway PDB
1 MAPK1 P28482 Mitogen-activated protein kinase 1 hsa01521; hsa01522; hsa01524; hsa04010; hsa04012; hsa04014; hsa04015; hsa04022; hsa04024; hsa04062; hsa04066; hsa04068; hsa04071; hsa04072; hsa04114; hsa04140; hsa04150; hsa04151; hsa04210; hsa04218; hsa04261; hsa04270; hsa04350; hsa04360; hsa04370; hsa04371; hsa04380; hsa04510; hsa04520; hsa04540; hsa04550; hsa04611; hsa04620; hsa04621; hsa04625; hsa04650; hsa04657; hsa04658; hsa04659; hsa04660; hsa04662; hsa04664; hsa04666; hsa04668; hsa04713; hsa04720; hsa04722; hsa04723; hsa04724; hsa04725; hsa04726; hsa04730; hsa04810; hsa04910; hsa04912; hsa04914; hsa04915; hsa04916; hsa04917; hsa04919; hsa04921; hsa04926; hsa04928; hsa04930; hsa04933; hsa04934; hsa04960; hsa05010; hsa05020; hsa05034; hsa05131; hsa05132; hsa05133; hsa05140; hsa05142; hsa05145; hsa05152; hsa05160; hsa05161; hsa05163; hsa05164; hsa05165; hsa05167; hsa05170; hsa05200; hsa05203; hsa05205; hsa05206; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05216; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231

18 known interactions (drugs) of input target (MAPK1): Mitogen-activated protein kinase 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB02482 Phosphonothreonine Thumb
2 Experimental SmallMoleculeDrug DB04338 SB220025 Thumb
3 Approved;
SmallMoleculeDrug DB01064 Isoprenaline Thumb
4 Experimental SmallMoleculeDrug DB07905 (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione Thumb
5 Experimental SmallMoleculeDrug DB07010 N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE Thumb
7 Experimental SmallMoleculeDrug DB02116 Olomoucine Thumb
8 Experimental SmallMoleculeDrug DB02733 Purvalanol Thumb
9 Approved;
SmallMoleculeDrug DB11120 Turpentine Thumb
10 Investigational SmallMoleculeDrug DB13930 Ulixertinib Thumb
11 Experimental SmallMoleculeDrug DB08521 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE Thumb
12 Investigational SmallMoleculeDrug DB06641 Perifosine Thumb
13 Experimental SmallMoleculeDrug DB07788 (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE Thumb
14 Approved;
SmallMoleculeDrug DB01169 Arsenic trioxide Thumb
15 Experimental SmallMoleculeDrug DB06877 N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE Thumb
16 Investigational SmallMoleculeDrug DB06195 Seliciclib Thumb
17 Experimental SmallMoleculeDrug DB07264 (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE Thumb
18 Experimental SmallMoleculeDrug DB07794 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE Thumb

20 predicted interactions (drugs) of input target (MAPK1): Mitogen-activated protein kinase 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB00143 Glutathione Thumb 37.7%
2 Experimental SmallMoleculeDrug DB03428 SU9516 Thumb 35.0%
3 Experimental SmallMoleculeDrug DB02950 Hymenialdisine Thumb 33.5%
4 Experimental SmallMoleculeDrug DB04137 Guanosine-5'-Triphosphate Thumb 29.7%
5 Approved;
SmallMoleculeDrug DB12965 Silver Thumb 28.4%
6 Experimental SmallMoleculeDrug DB04604 5-iodotubercidin Thumb 27.0%
7 Approved;
SmallMoleculeDrug DB00914 Phenformin Thumb 26.1%
8 Approved SmallMoleculeDrug DB00217 Bethanidine Thumb 25.0%
9 Approved;
SmallMoleculeDrug DB01142 Doxepin Thumb 24.9%
10 Experimental SmallMoleculeDrug DB08342 S-PALMITOYL-L-CYSTEINE Thumb 24.4%
11 Approved;
SmallMoleculeDrug DB00909 Zonisamide Thumb 24.3%
12 Experimental SmallMoleculeDrug DB03374 3,5-Diiodotyrosine Thumb 24.2%
13 Approved;
SmallMoleculeDrug DB06144 Sertindole Thumb 24.0%
14 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 23.3%
15 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 22.8%
16 Experimental SmallMoleculeDrug DB02052 Indirubin-3'-Monoxime Thumb 22.7%
17 Experimental SmallMoleculeDrug DB08096 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM Thumb 22.5%
18 Approved;
SmallMoleculeDrug DB01136 Carvedilol Thumb 22.4%
19 Investigational SmallMoleculeDrug DB05037 AT7519 Thumb 22.3%
20 Approved;
SmallMoleculeDrug DB02325 Isopropyl Alcohol Thumb 22.3%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.