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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P28566
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR1E P28566 5-hydroxytryptamine receptor 1E hsa04024; hsa04080; hsa04726; hsa04742 NA


15 known interactions (drugs) of input target (HTR1E): 5-hydroxytryptamine receptor 1E
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
2 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00216 Eletriptan Thumb
5 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
6 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
7 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
8 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
9 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
10 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
11 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
12 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
13 Approved SmallMoleculeDrug DB00247 Methysergide Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb


20 predicted interactions (drugs) of input target (HTR1E): 5-hydroxytryptamine receptor 1E
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 83.3%
2 Approved SmallMoleculeDrug DB06216 Asenapine Thumb 81.2%
3 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 81.2%
4 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 80.9%
5 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 80.1%
6 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb 79.7%
7 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 79.2%
8 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb 78.9%
9 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb 78.2%
10 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb 77.7%
11 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 76.4%
12 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb 75.4%
13 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb 75.1%
14 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb 74.6%
15 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb 74.3%
16 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb 74.1%
17 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 73.9%
18 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb 73.9%
19 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb 73.8%
20 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb 73.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.