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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P48048
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNJ1 P48048 ATP-sensitive inward rectifier potassium channel 1 hsa04960; hsa04971 NA


9 known interactions (drugs) of input target (KCNJ1): ATP-sensitive inward rectifier potassium channel 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00217 Bethanidine Thumb
2 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB00350 Minoxidil Thumb
4 Experimental;
Investigational		 SmallMoleculeDrug DB08838 Agmatine Thumb
5 Approved SmallMoleculeDrug DB00222 Glimepiride Thumb
6 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb
7 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00414 Acetohexamide Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB01124 Tolbutamide Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB01382 Glycodiazine Thumb


20 predicted interactions (drugs) of input target (KCNJ1): ATP-sensitive inward rectifier potassium channel 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00839 Tolazamide Thumb 38.7%
2 Approved;
Investigational		 SmallMoleculeDrug DB01251 Gliquidone Thumb 37.6%
3 Approved;
Investigational		 SmallMoleculeDrug DB00922 Levosimendan Thumb 36.2%
4 Approved SmallMoleculeDrug DB01016 Glyburide Thumb 35.5%
5 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb 31.0%
6 Approved SmallMoleculeDrug DB01592 Iron Thumb 30.9%
7 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 29.6%
8 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 29.0%
9 Approved SmallMoleculeDrug DB00363 Clozapine Thumb 28.9%
10 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 28.7%
11 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb 28.3%
12 Approved;
Investigational		 SmallMoleculeDrug DB01136 Carvedilol Thumb 27.6%
13 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 27.2%
14 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb 26.5%
15 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb 26.4%
16 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb 26.0%
17 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 26.0%
18 Experimental SmallMoleculeDrug DB01699 (4e)-4-Aminohex-4-Enoic Acid Thumb 25.8%
19 Approved;
Investigational		 SmallMoleculeDrug DB01067 Glipizide Thumb 25.8%
20 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 25.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.