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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P41145
No. Gene UniProt ID Protein Name Pathway PDB
1 OPRK1 P41145 Kappa-type opioid receptor hsa04080 2A0D; 2IQN; 4DJH


49 known interactions (drugs) of input target (OPRK1): Kappa-type opioid receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00497 Oxycodone Thumb
2 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb
3 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
4 Approved SmallMoleculeDrug DB00836 Loperamide Thumb
5 Investigational SmallMoleculeDrug DB14146 Loxicodegol Thumb
6 Investigational SmallMoleculeDrug DB05104 Asimadoline Thumb
7 Approved SmallMoleculeDrug DB00854 Levorphanol Thumb
8 Illicit SmallMoleculeDrug DB01571 3-Methylfentanyl Thumb
9 Approved;
Illicit		 SmallMoleculeDrug DB09209 Pholcodine Thumb
10 Approved;
Illicit		 SmallMoleculeDrug DB11130 Opium Thumb
11 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
12 Illicit;
Vet approved		 SmallMoleculeDrug DB01548 Diprenorphine Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB11186 Pentoxyverine Thumb
14 Experimental;
Illicit		 SmallMoleculeDrug DB01439 3-Methylthiofentanyl Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB00295 Morphine Thumb
16 Approved;
Investigational		 SmallMoleculeDrug DB06738 Ketobemidone Thumb
17 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00647 Dextropropoxyphene Thumb
18 Illicit;
Vet approved		 SmallMoleculeDrug DB01497 Etorphine Thumb
19 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
20 Experimental;
Illicit		 SmallMoleculeDrug DB01565 Dihydromorphine Thumb
21 Approved;
Investigational		 SmallMoleculeDrug DB11691 Naldemedine Thumb
22 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00704 Naltrexone Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB09272 Eluxadoline Thumb
24 Investigational SmallMoleculeDrug DB05443 ADL 10-0101 Thumb
25 Investigational SmallMoleculeDrug DB05155 CR665 Thumb
26 Approved;
Vet approved		 SmallMoleculeDrug DB00396 Progesterone Thumb
27 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb
28 Investigational SmallMoleculeDrug DB05046 V1003 Thumb
29 Approved;
Illicit		 SmallMoleculeDrug DB00327 Hydromorphone Thumb
30 Approved;
Investigational		 SmallMoleculeDrug DB00708 Sufentanil Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
32 Approved;
Vet approved		 SmallMoleculeDrug DB00652 Pentazocine Thumb
33 Approved SmallMoleculeDrug DB00454 Pethidine Thumb
34 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB01452 Heroin Thumb
35 Approved;
Illicit		 SmallMoleculeDrug DB00318 Codeine Thumb
36 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00921 Buprenorphine Thumb
37 Approved;
Illicit;
Vet approved		 SmallMoleculeDrug DB00611 Butorphanol Thumb
38 Approved;
Vet approved		 SmallMoleculeDrug DB01183 Naloxone Thumb
39 Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB01535 Carfentanil Thumb
40 Approved;
Investigational		 SmallMoleculeDrug DB01209 Dezocine Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB06274 Alvimopan Thumb
42 Approved SmallMoleculeDrug DB00825 Menthol Thumb
43 Approved SmallMoleculeDrug DB06800 Methylnaltrexone Thumb
44 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06230 Nalmefene Thumb
45 Approved SmallMoleculeDrug DB00844 Nalbuphine Thumb
46 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
47 Approved SmallMoleculeDrug DB00899 Remifentanil Thumb
48 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00813 Fentanyl Thumb
49 Approved SmallMoleculeDrug DB06204 Tapentadol Thumb


20 predicted interactions (drugs) of input target (OPRK1): Kappa-type opioid receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb 83.4%
2 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb 78.7%
3 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb 77.9%
4 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb 75.6%
5 Experimental;
Illicit		 SmallMoleculeDrug DB01444 Dimethylthiambutene Thumb 74.4%
6 Approved SmallMoleculeDrug DB00333 Methadone Thumb 73.9%
7 Approved;
Illicit		 SmallMoleculeDrug DB00956 Hydrocodone Thumb 71.6%
8 Approved;
Illicit		 SmallMoleculeDrug DB01081 Diphenoxylate Thumb 70.4%
9 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01192 Oxymorphone Thumb 69.5%
10 Approved SmallMoleculeDrug DB00904 Ondansetron Thumb 68.8%
11 Investigational SmallMoleculeDrug DB05509 LI-301 Thumb 68.8%
12 Approved;
Investigational		 SmallMoleculeDrug DB09289 Tianeptine Thumb 68.3%
13 Approved SmallMoleculeDrug DB09049 Naloxegol Thumb 66.9%
14 Approved;
Illicit		 SmallMoleculeDrug DB00913 Anileridine Thumb 64.6%
15 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 63.4%
16 Investigational SmallMoleculeDrug DB05050 ADL5859 Thumb 62.6%
17 Approved;
Illicit		 SmallMoleculeDrug DB01433 Methadyl Acetate Thumb 62.5%
18 Approved;
Investigational		 SmallMoleculeDrug DB01227 Levomethadyl Acetate Thumb 60.3%
19 Approved;
Illicit		 SmallMoleculeDrug DB01466 Ethylmorphine Thumb 59.0%
20 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 57.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.