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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P18089
No. Gene UniProt ID Protein Name Pathway PDB
1 ADRA2B P18089 Alpha-2B adrenergic receptor hsa04022; hsa04080 2CVA


75 known interactions (drugs) of input target (ADRA2B): Alpha-2B adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Vet approved SmallMoleculeDrug DB11477 Xylazine Thumb
2 Investigational SmallMoleculeDrug DB06678 Esmirtazapine Thumb
3 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB01018 Guanfacine Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
6 Approved;
Vet approved		 SmallMoleculeDrug DB00668 Epinephrine Thumb
7 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
8 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb
9 Approved SmallMoleculeDrug DB05271 Rotigotine Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB04846 Celiprolol Thumb
11 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
12 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
13 Approved;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB00397 Phenylpropanolamine Thumb
14 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
15 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
16 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb
17 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
19 Approved;
Investigational		 SmallMoleculeDrug DB06694 Xylometazoline Thumb
20 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb
21 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
22 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
23 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB00629 Guanabenz Thumb
25 Approved SmallMoleculeDrug DB00484 Brimonidine Thumb
26 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb
27 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
28 Approved SmallMoleculeDrug DB01365 Mephentermine Thumb
29 Approved;
Vet approved		 SmallMoleculeDrug DB00797 Tolazoline Thumb
30 Approved SmallMoleculeDrug DB00964 Apraclonidine Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
32 Approved SmallMoleculeDrug DB11577 Indigotindisulfonic Acid Thumb
33 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb
35 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
36 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
37 Approved SmallMoleculeDrug DB11124 Racepinephrine Thumb
38 Approved SmallMoleculeDrug DB00217 Bethanidine Thumb
39 Approved SmallMoleculeDrug DB09195 Lorpiprazole Thumb
40 Approved SmallMoleculeDrug DB00800 Fenoldopam Thumb
41 Approved SmallMoleculeDrug DB00457 Prazosin Thumb
42 Approved;
Investigational		 SmallMoleculeDrug DB01136 Carvedilol Thumb
43 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb
44 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
45 Approved;
Investigational		 SmallMoleculeDrug DB09205 Moxisylyte Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
47 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
48 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
49 Approved SmallMoleculeDrug DB00575 Clonidine Thumb
50 Approved;
Investigational		 SmallMoleculeDrug DB00935 Oxymetazoline Thumb
51 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
52 Approved;
Investigational		 SmallMoleculeDrug DB00697 Tizanidine Thumb
53 Approved SmallMoleculeDrug DB00292 Etomidate Thumb
54 Approved SmallMoleculeDrug DB06707 Levonordefrin Thumb
55 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
56 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
57 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
58 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb
59 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
60 Experimental SmallMoleculeDrug DB09202 Cirazoline Thumb
61 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
62 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
63 Approved;
Illicit		 SmallMoleculeDrug DB01577 Methamphetamine Thumb
64 Approved;
Nutraceutical;
Withdrawn		 SmallMoleculeDrug DB01363 Ephedra Thumb
65 Approved SmallMoleculeDrug DB11278 DL-Methylephedrine Thumb
66 Approved SmallMoleculeDrug DB00925 Phenoxybenzamine Thumb
67 Investigational SmallMoleculeDrug DB05461 OPC-28326 Thumb
68 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
69 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb
70 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
71 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
72 Approved;
Investigational		 SmallMoleculeDrug DB06262 Droxidopa Thumb
73 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
74 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
75 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb


20 predicted interactions (drugs) of input target (ADRA2B): Alpha-2B adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 93.6%
2 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb 91.7%
3 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 91.6%
4 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 91.3%
5 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb 90.0%
6 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb 89.2%
7 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb 89.1%
8 Approved;
Investigational		 SmallMoleculeDrug DB09128 Brexpiprazole Thumb 88.0%
9 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb 87.4%
10 Approved;
Investigational		 SmallMoleculeDrug DB01608 Propericiazine Thumb 87.4%
11 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb 87.4%
12 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb 86.0%
13 Approved;
Investigational		 SmallMoleculeDrug DB00320 Dihydroergotamine Thumb 85.7%
14 Approved;
Investigational		 SmallMoleculeDrug DB00656 Trazodone Thumb 85.4%
15 Approved SmallMoleculeDrug DB08922 Perospirone Thumb 83.8%
16 Experimental;
Illicit		 SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb 82.7%
17 Approved SmallMoleculeDrug DB00449 Dipivefrin Thumb 82.0%
18 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb 81.4%
19 Approved;
Vet approved		 SmallMoleculeDrug DB01614 Acepromazine Thumb 80.9%
20 Approved;
Investigational		 SmallMoleculeDrug DB09242 Moxonidine Thumb 80.6%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.