QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9UNK4
No. Gene UniProt ID Protein Name Pathway PDB
1 PLA2G2D Q9UNK4 Group IID secretory phospholipase A2 hsa00564; hsa00565; hsa00590; hsa00591; hsa00592; hsa01100; hsa04014; hsa04270; hsa04972; hsa04975 NA


2 known interactions (drugs) of input target (PLA2G2D): Group IID secretory phospholipase A2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Experimental		 SmallMoleculeDrug DB03193 Stearic acid Thumb
2 Approved;
Experimental		 SmallMoleculeDrug DB03017 Lauric Acid Thumb


20 predicted interactions (drugs) of input target (PLA2G2D): Group IID secretory phospholipase A2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb 19.7%
2 Investigational SmallMoleculeDrug DB12961 Leukotriene B4 Thumb 19.3%
3 Approved;
Investigational		 SmallMoleculeDrug DB00328 Indomethacin Thumb 19.1%
4 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb 19.0%
5 Experimental SmallMoleculeDrug DB04137 Guanosine-5'-Triphosphate Thumb 18.8%
6 Approved;
Investigational		 SmallMoleculeDrug DB12007 Isoflavone Thumb 16.6%
7 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb 16.0%
8 Approved;
Investigational		 SmallMoleculeDrug DB09064 Ciprofibrate Thumb 15.9%
9 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 15.7%
10 Experimental SmallMoleculeDrug DB02767 3-Hydroxy-Myristic Acid Thumb 15.5%
11 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 15.5%
12 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB04224 Oleic Acid Thumb 15.4%
13 Approved;
Investigational		 SmallMoleculeDrug DB01136 Carvedilol Thumb 15.3%
14 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb 15.3%
15 Approved SmallMoleculeDrug DB09244 Pirlindole Thumb 15.3%
16 Approved;
Nutraceutical		 SmallMoleculeDrug DB00139 Succinic acid Thumb 15.2%
17 Experimental SmallMoleculeDrug DB03721 N-acetyl-alpha-neuraminic acid Thumb 14.9%
18 Approved;
Investigational		 SmallMoleculeDrug DB01132 Pioglitazone Thumb 14.7%
19 Experimental SmallMoleculeDrug DB04153 S-Hydroxymethyl Glutathione Thumb 14.7%
20 Experimental SmallMoleculeDrug DB02266 Flufenamic Acid Thumb 14.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.