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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P28223
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR2A P28223 5-hydroxytryptamine receptor 2A hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 NA


112 known interactions (drugs) of input target (HTR2A): 5-hydroxytryptamine receptor 2A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB06678 Esmirtazapine Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB09223 Blonanserin Thumb
3 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb
4 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
5 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB06016 Cariprazine Thumb
8 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
9 Approved SmallMoleculeDrug DB01623 Thiothixene Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb
11 Investigational SmallMoleculeDrug DB06446 Dotarizine Thumb
12 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb
13 Approved SmallMoleculeDrug DB00502 Haloperidol Thumb
14 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb
15 Investigational SmallMoleculeDrug DB05687 BL-1020 Thumb
16 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
17 Investigational SmallMoleculeDrug DB12555 Nelotanserin Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
19 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb
20 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
21 Approved;
Withdrawn		 SmallMoleculeDrug DB00409 Remoxipride Thumb
22 Approved SmallMoleculeDrug DB00623 Fluphenazine Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
24 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01079 Tegaserod Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
26 Investigational SmallMoleculeDrug DB12693 Ritanserin Thumb
27 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
28 Approved;
Investigational		 SmallMoleculeDrug DB00656 Trazodone Thumb
29 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb
30 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb
31 Approved SmallMoleculeDrug DB00805 Minaprine Thumb
32 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb
33 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB08810 Cinitapride Thumb
35 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
36 Approved;
Investigational		 SmallMoleculeDrug DB09128 Brexpiprazole Thumb
37 Approved SmallMoleculeDrug DB08922 Perospirone Thumb
38 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
39 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb
40 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB01621 Pipotiazine Thumb
42 Experimental SmallMoleculeDrug DB13940 2,5-Dimethoxy-4-ethylthioamphetamine Thumb
43 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb
44 Investigational SmallMoleculeDrug DB12465 Ketanserin Thumb
45 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
46 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
47 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
48 Investigational SmallMoleculeDrug DB06512 Deramciclane Thumb
49 Investigational SmallMoleculeDrug DB05227 APD791 Thumb
50 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
51 Experimental;
Illicit		 SmallMoleculeDrug DB01488 Dimethyltryptamine Thumb
52 Investigational SmallMoleculeDrug DB12163 Sarpogrelate Thumb
53 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb
54 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
55 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
56 Approved SmallMoleculeDrug DB00924 Cyclobenzaprine Thumb
57 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb
58 Experimental SmallMoleculeDrug DB08927 Amperozide Thumb
59 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
60 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
61 Approved;
Withdrawn		 SmallMoleculeDrug DB00679 Thioridazine Thumb
62 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00604 Cisapride Thumb
63 Approved SmallMoleculeDrug DB00247 Methysergide Thumb
64 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb
65 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
66 Investigational;
Nutraceutical		 SmallMoleculeDrug DB08839 Serotonin Thumb
67 Approved SmallMoleculeDrug DB09195 Lorpiprazole Thumb
68 Approved;
Investigational		 SmallMoleculeDrug DB01069 Promethazine Thumb
69 Approved SmallMoleculeDrug DB09016 Butriptyline Thumb
70 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
71 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
72 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
73 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
74 Investigational SmallMoleculeDrug DB06077 Lumateperone Thumb
75 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
76 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb
77 Approved;
Investigational		 SmallMoleculeDrug DB04908 Flibanserin Thumb
78 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
79 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb
80 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00574 Fenfluramine Thumb
81 Experimental;
Illicit		 SmallMoleculeDrug DB14010 5-methoxy-N,N-dimethyltryptamine Thumb
82 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
83 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
84 Experimental;
Illicit		 SmallMoleculeDrug DB01537 4-Bromo-2,5-dimethoxyphenethylamine Thumb
85 Approved;
Investigational		 SmallMoleculeDrug DB05316 Pimavanserin Thumb
86 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
87 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb
88 Approved SmallMoleculeDrug DB00843 Donepezil Thumb
89 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
90 Approved;
Investigational		 SmallMoleculeDrug DB06288 Amisulpride Thumb
91 Approved;
Investigational		 SmallMoleculeDrug DB00933 Mesoridazine Thumb
92 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb
93 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb
94 Approved;
Investigational		 SmallMoleculeDrug DB04842 Fluspirilene Thumb
95 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01242 Clomipramine Thumb
96 Investigational SmallMoleculeDrug DB05079 HY10275 Thumb
97 Approved;
Vet approved		 SmallMoleculeDrug DB01614 Acepromazine Thumb
98 Experimental SmallMoleculeDrug DB04599 Aniracetam Thumb
99 Approved SmallMoleculeDrug DB01618 Molindone Thumb
100 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
101 Experimental SmallMoleculeDrug DB13948 N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine Thumb
102 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00875 Flupentixol Thumb
103 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb
104 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
105 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb
106 Experimental;
Illicit		 SmallMoleculeDrug DB01442 MMDA Thumb
107 Approved;
Investigational		 SmallMoleculeDrug DB00715 Paroxetine Thumb
108 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
109 Experimental;
Illicit;
Investigational		 SmallMoleculeDrug DB01454 Midomafetamine Thumb
110 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
111 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
112 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb


20 predicted interactions (drugs) of input target (HTR2A): 5-hydroxytryptamine receptor 2A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb 87.0%
2 Approved SmallMoleculeDrug DB00215 Citalopram Thumb 83.1%
3 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 81.2%
4 Approved SmallMoleculeDrug DB00800 Fenoldopam Thumb 79.0%
5 Approved SmallMoleculeDrug DB05271 Rotigotine Thumb 78.7%
6 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb 78.6%
7 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb 78.6%
8 Approved;
Investigational		 SmallMoleculeDrug DB01233 Metoclopramide Thumb 77.4%
9 Investigational SmallMoleculeDrug DB05461 OPC-28326 Thumb 76.9%
10 Approved;
Vet approved		 SmallMoleculeDrug DB00508 Triflupromazine Thumb 75.6%
11 Investigational SmallMoleculeDrug DB05766 ACP-104 Thumb 74.6%
12 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb 74.5%
13 Approved;
Investigational		 SmallMoleculeDrug DB00831 Trifluoperazine Thumb 74.1%
14 Approved;
Investigational		 SmallMoleculeDrug DB00216 Eletriptan Thumb 73.0%
15 Approved;
Investigational		 SmallMoleculeDrug DB09097 Quinagolide Thumb 72.8%
16 Approved;
Vet approved		 SmallMoleculeDrug DB00472 Fluoxetine Thumb 72.2%
17 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb 72.1%
18 Approved;
Investigational		 SmallMoleculeDrug DB00320 Dihydroergotamine Thumb 71.4%
19 Approved;
Investigational		 SmallMoleculeDrug DB01608 Propericiazine Thumb 71.3%
20 Investigational SmallMoleculeDrug DB12061 Pardoprunox Thumb 71.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.