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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q05940
No. Gene UniProt ID Protein Name Pathway PDB
1 SLC18A2 Q05940 Synaptic vesicular amine transporter hsa04721; hsa04726; hsa04728; hsa05012; hsa05030; hsa05031; hsa05034 NA


23 known interactions (drugs) of input target (SLC18A2): Synaptic vesicular amine transporter
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB06714 Propylhexedrine Thumb
2 Experimental;
Illicit;
Investigational		 SmallMoleculeDrug DB01454 Midomafetamine Thumb
3 Investigational SmallMoleculeDrug DB09363 Rauwolfia serpentina root Thumb
4 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb
5 Approved;
Illicit		 SmallMoleculeDrug DB01576 Dextroamphetamine Thumb
6 Approved SmallMoleculeDrug DB06706 Isometheptene Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB00206 Reserpine Thumb
8 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
9 Approved;
Illicit		 SmallMoleculeDrug DB01577 Methamphetamine Thumb
10 Approved;
Illicit		 SmallMoleculeDrug DB00865 Benzphetamine Thumb
11 Approved;
Investigational		 SmallMoleculeDrug DB12161 Deutetrabenazine Thumb
12 Approved SmallMoleculeDrug DB00502 Haloperidol Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB00579 Mazindol Thumb
14 Investigational;
Nutraceutical		 SmallMoleculeDrug DB08839 Serotonin Thumb
15 Approved SmallMoleculeDrug DB01364 Ephedrine Thumb
16 Approved;
Investigational		 SmallMoleculeDrug DB05381 Histamine Thumb
17 Withdrawn SmallMoleculeDrug DB04821 Nomifensine Thumb
18 Experimental;
Illicit		 SmallMoleculeDrug DB01442 MMDA Thumb
19 Approved;
Investigational		 SmallMoleculeDrug DB04844 Tetrabenazine Thumb
20 Experimental;
Illicit		 SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb
21 Approved SmallMoleculeDrug DB01089 Deserpidine Thumb
22 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
23 Approved;
Nutraceutical;
Withdrawn		 SmallMoleculeDrug DB01363 Ephedra Thumb


20 predicted interactions (drugs) of input target (SLC18A2): Synaptic vesicular amine transporter
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 58.2%
2 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 58.0%
3 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 57.5%
4 Approved;
Investigational		 SmallMoleculeDrug DB01175 Escitalopram Thumb 57.2%
5 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 56.1%
6 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 55.9%
7 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb 55.4%
8 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 55.1%
9 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb 54.1%
10 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 52.3%
11 Approved SmallMoleculeDrug DB00408 Loxapine Thumb 52.2%
12 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 51.3%
13 Approved;
Investigational		 SmallMoleculeDrug DB00656 Trazodone Thumb 51.0%
14 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb 50.3%
15 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb 50.2%
16 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb 49.8%
17 Approved;
Investigational		 SmallMoleculeDrug DB00422 Methylphenidate Thumb 49.5%
18 Investigational SmallMoleculeDrug DB12305 Dasotraline Thumb 49.4%
19 Investigational SmallMoleculeDrug DB04889 Bicifadine Thumb 49.2%
20 Approved SmallMoleculeDrug DB00476 Duloxetine Thumb 49.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.