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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P06744
No. Gene UniProt ID Protein Name Pathway PDB
1 GPI P06744 Glucose-6-phosphate isomerase hsa00010; hsa00030; hsa00500; hsa00520; hsa01100; hsa01200 1IAT; 1IRI; 1JIQ; 1JLH; 1NUH

10 known interactions (drugs) of input target (GPI): Glucose-6-phosphate isomerase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB02007 alpha-D-glucose 6-phosphate Thumb
2 Experimental SmallMoleculeDrug DB03581 Glucose-6-Phosphate Thumb
3 Experimental SmallMoleculeDrug DB03937 Erythose-4-Phosphate Thumb
4 Approved;
SmallMoleculeDrug DB09130 Copper Thumb
5 Experimental SmallMoleculeDrug DB03042 5-Phosphoarabinonic Acid Thumb
6 Experimental SmallMoleculeDrug DB04493 Fructose-6-Phosphate Thumb
7 Approved;
SmallMoleculeDrug DB11638 Artenimol Thumb
8 Experimental SmallMoleculeDrug DB02076 6-phospho-D-gluconic acid Thumb
9 Experimental SmallMoleculeDrug DB02093 5-Phospho-D-Arabinohydroxamic Acid Thumb
10 Experimental SmallMoleculeDrug DB02548 D-glucitol 6-phosphate Thumb

20 predicted interactions (drugs) of input target (GPI): Glucose-6-phosphate isomerase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 45.8%
2 Experimental SmallMoleculeDrug DB03814 2-(N-Morpholino)-Ethanesulfonic Acid Thumb 30.8%
3 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 27.8%
4 Experimental SmallMoleculeDrug DB04315 Guanosine-5'-Diphosphate Thumb 27.5%
5 Experimental SmallMoleculeDrug DB02483 Etheno-Nad Thumb 26.1%
6 Experimental SmallMoleculeDrug DB07374 Anisomycin Thumb 25.7%
7 Approved BiotechDrug DB00031 Tenecteplase Thumb 25.0%
8 Experimental SmallMoleculeDrug DB08437 Puromycin Thumb 23.5%
9 Investigational BiotechDrug DB06245 Lanoteplase Thumb 23.3%
10 Approved SmallMoleculeDrug DB09118 Stiripentol Thumb 23.1%
11 Experimental SmallMoleculeDrug DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose Thumb 22.8%
12 Approved SmallMoleculeDrug DB11157 Anthralin Thumb 22.6%
13 Approved;
Vet approved
SmallMoleculeDrug DB04272 Citric Acid Thumb 22.4%
14 Experimental SmallMoleculeDrug DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Thumb 22.0%
15 Experimental SmallMoleculeDrug DB03501 Galactose-uridine-5'-diphosphate Thumb 21.3%
16 Approved;
SmallMoleculeDrug DB00142 Glutamic Acid Thumb 20.4%
17 Experimental SmallMoleculeDrug DB04805 Virginiamycin S1 Thumb 20.2%
18 Nutraceutical SmallMoleculeDrug DB00116 Tetrahydrofolic acid Thumb 19.1%
19 Approved;
SmallMoleculeDrug DB00908 Quinidine Thumb 19.0%
20 Approved SmallMoleculeDrug DB00515 Cisplatin Thumb 19.0%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.