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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P49356
No. Gene UniProt ID Protein Name Pathway PDB
1 FNTB P49356 Protein farnesyltransferase subunit beta NA 1JCQ; 1LD7; 1LD8; 1MZC; 1S63; 1SA4; 1TN6; 2F0Y; 2H6F; 2H6G; 2H6H; 2H6I; 2IEJ; 3E37


11 known interactions (drugs) of input target (FNTB): Protein farnesyltransferase subunit beta
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB06953 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE Thumb
2 Investigational SmallMoleculeDrug DB04893 AZD3409 Thumb
3 Experimental SmallMoleculeDrug DB07895 ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID Thumb
4 Experimental SmallMoleculeDrug DB07771 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Thumb
5 Experimental SmallMoleculeDrug DB07227 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE Thumb
6 Experimental SmallMoleculeDrug DB07841 Geranylgeranyl diphosphate Thumb
7 Investigational SmallMoleculeDrug DB04960 Tipifarnib Thumb
8 Experimental SmallMoleculeDrug DB08674 (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE Thumb
9 Experimental SmallMoleculeDrug DB07780 FARNESYL DIPHOSPHATE Thumb
10 Experimental SmallMoleculeDrug DB07216 (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE Thumb
11 Experimental SmallMoleculeDrug DB08676 (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE Thumb


20 predicted interactions (drugs) of input target (FNTB): Protein farnesyltransferase subunit beta
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB08180 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE Thumb 60.3%
2 Investigational SmallMoleculeDrug DB06448 Lonafarnib Thumb 43.1%
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb 30.2%
4 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb 27.6%
5 Approved;
Investigational		 SmallMoleculeDrug DB00996 Gabapentin Thumb 25.6%
6 Investigational SmallMoleculeDrug DB05171 E-2012 Thumb 24.3%
7 Experimental SmallMoleculeDrug DB01717 Bis(Adenosine)-5'-Pentaphosphate Thumb 21.2%
8 Approved;
Investigational		 SmallMoleculeDrug DB01296 Glucosamine Thumb 21.0%
9 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 19.5%
10 Approved;
Withdrawn		 SmallMoleculeDrug DB00761 Potassium Chloride Thumb 19.2%
11 Investigational SmallMoleculeDrug DB05184 XL228 Thumb 18.8%
12 Approved SmallMoleculeDrug DB09118 Stiripentol Thumb 18.7%
13 Experimental SmallMoleculeDrug DB04695 FARNESYL THIOPYROPHOSPHATE Thumb 18.5%
14 Approved;
Investigational		 SmallMoleculeDrug DB01064 Isoprenaline Thumb 17.8%
15 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb 17.6%
16 Experimental SmallMoleculeDrug DB07697 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Thumb 17.6%
17 Approved;
Investigational		 SmallMoleculeDrug DB08889 Carfilzomib Thumb 17.5%
18 Experimental SmallMoleculeDrug DB07045 (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Thumb 17.5%
19 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb 17.2%
20 Approved;
Investigational;
Withdrawn		 BiotechDrug DB00055 Drotrecogin alfa Thumb 17.2%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.