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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P04181
No. Gene UniProt ID Protein Name Pathway PDB
1 OAT P04181 Ornithine aminotransferase, mitochondrial hsa00330; hsa01100 1GBN; 1OAT; 2BYJ; 2BYL; 2CAN; 2OAT


4 known interactions (drugs) of input target (OAT): Ornithine aminotransferase, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB02054 Gabaculine Thumb
2 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb
3 Experimental SmallMoleculeDrug DB02821 Canaline Thumb
4 Approved;
Nutraceutical		 SmallMoleculeDrug DB00129 Ornithine Thumb


20 predicted interactions (drugs) of input target (OAT): Ornithine aminotransferase, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb 35.7%
2 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 31.5%
3 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 24.7%
4 Experimental SmallMoleculeDrug DB02142 Pyridoxamine-5'-Phosphate Thumb 21.7%
5 Approved;
Nutraceutical		 SmallMoleculeDrug DB00125 L-Arginine Thumb 20.8%
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb 20.6%
7 Experimental SmallMoleculeDrug DB08342 S-PALMITOYL-L-CYSTEINE Thumb 20.5%
8 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB04272 Citric Acid Thumb 20.3%
9 Experimental SmallMoleculeDrug DB02556 D-Phenylalanine Thumb 19.2%
10 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb 18.9%
11 Approved BiotechDrug DB06404 Human C1-esterase inhibitor Thumb 17.8%
12 Approved;
Nutraceutical		 SmallMoleculeDrug DB06757 Manganese Thumb 16.8%
13 Experimental SmallMoleculeDrug DB01902 1-Ethyl-Pyrrolidine-2,5-Dione Thumb 16.5%
14 Experimental SmallMoleculeDrug DB04652 Corticosterone Thumb 16.2%
15 Experimental SmallMoleculeDrug DB03814 2-(N-Morpholino)-Ethanesulfonic Acid Thumb 15.8%
16 Approved;
Nutraceutical		 SmallMoleculeDrug DB00126 Vitamin C Thumb 15.8%
17 Approved;
Nutraceutical		 SmallMoleculeDrug DB00151 L-Cysteine Thumb 15.8%
18 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB01942 Formic Acid Thumb 15.6%
19 Approved;
Investigational		 SmallMoleculeDrug DB01143 Amifostine Thumb 15.6%
20 Approved;
Nutraceutical		 SmallMoleculeDrug DB00160 L-Alanine Thumb 15.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.