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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9NY47
No. Gene UniProt ID Protein Name Pathway PDB
1 CACNA2D2 Q9NY47 Voltage-dependent calcium channel subunit alpha-2/delta-2 hsa04010; hsa04260; hsa04261; hsa04921; hsa05410; hsa05412; hsa05414 NA


9 known interactions (drugs) of input target (CACNA2D2): Voltage-dependent calcium channel subunit alpha-2/delta-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB08872 Gabapentin Enacarbil Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB01023 Felodipine Thumb
4 Approved;
Withdrawn		 SmallMoleculeDrug DB01244 Bepridil Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB00270 Isradipine Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB00996 Gabapentin Thumb
7 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB01118 Amiodarone Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB01054 Nitrendipine Thumb


20 predicted interactions (drugs) of input target (CACNA2D2): Voltage-dependent calcium channel subunit alpha-2/delta-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB06712 Nilvadipine Thumb 57.3%
2 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 56.3%
3 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 56.0%
4 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 54.6%
5 Approved SmallMoleculeDrug DB00401 Nisoldipine Thumb 54.4%
6 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00653 Magnesium sulfate Thumb 53.8%
7 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 53.5%
8 Approved;
Investigational		 SmallMoleculeDrug DB09231 Benidipine Thumb 53.4%
9 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb 52.7%
10 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 51.1%
11 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb 50.0%
12 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 49.4%
13 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 48.3%
14 Approved;
Investigational		 SmallMoleculeDrug DB09238 Manidipine Thumb 45.7%
15 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb 45.6%
16 Approved SmallMoleculeDrug DB00825 Menthol Thumb 43.1%
17 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb 41.6%
18 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb 40.6%
19 Approved;
Investigational		 SmallMoleculeDrug DB09232 Cilnidipine Thumb 40.2%
20 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 38.0%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.