QuartataWeb 1.0

15 known interactions (drugs) of input target (APP): Amyloid beta A4 protein

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter
1	Approved	SmallMoleculeDrug	DB06782	Dimercaprol	OCC(S)CS
2	Approved; Investigational	SmallMoleculeDrug	DB09149	Florbetapir (18F)	[H]N(C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])N=C(OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[18F])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H]
3	Investigational	SmallMoleculeDrug	DB05938	Edonerpic	OC1CN(CCCOCCC2=CC3=C(SC=C3)C=C2)C1
4	Approved	SmallMoleculeDrug	DB09148	Florbetaben (18F)	CNC1=CC=C(\C=C\C2=CC=C(OCCOCCOCC[18F])C=C2)C=C1
5	Approved; Investigational	SmallMoleculeDrug	DB01593	Zinc	[Zn]
6	Approved; Investigational	SmallMoleculeDrug	DB09130	Copper	[Cu]
7	Approved; Experimental; Investigational	SmallMoleculeDrug	DB02709	Resveratrol	OC1=CC=C(\C=C\C2=CC(O)=CC(O)=C2)C=C1
8	Approved; Investigational	SmallMoleculeDrug	DB00746	Deferoxamine	CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
9	Experimental	SmallMoleculeDrug	DB02235	L-methionine (R)-S-oxide	C[S@@](=O)CC[C@H](N)C(O)=O
10	Investigational	SmallMoleculeDrug	DB05846	Mito-4509	NA
11	Approved; Investigational	SmallMoleculeDrug	DB09151	Flutemetamol (18F)	CNC1=C([18F])C=C(C=C1)C1=NC2=CC=C(O)C=C2S1
12	Investigational	SmallMoleculeDrug	DB05088	Tiomolibdate ion	[SH-].[SH-].S=[Mo]=S
13	Approved; Investigational	SmallMoleculeDrug	DB01370	Aluminium	[Al]
14	Investigational	SmallMoleculeDrug	DB04892	Phenserine	[H][C@]12N(C)CC[C@@]1(C)C1=C(C=CC(OC(=O)NC3=CC=CC=C3)=C1)N2C
15	Investigational	SmallMoleculeDrug	DB05150	CAD106	NA

20 predicted interactions (drugs) of input target (APP): Amyloid beta A4 protein

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Experimental	SmallMoleculeDrug	DB08492	(2E)-3-(2-OCT-1-YN-1-YLPHENYL)ACRYLIC ACID	CCCCCCC#CC1=CC=CC=C1\C=C\C(O)=O	34.3%
2	Investigational; Nutraceutical	SmallMoleculeDrug	DB00171	ATP	NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O	27.7%
3	Approved; Nutraceutical; Vet approved	SmallMoleculeDrug	DB01065	Melatonin	COC1=CC2=C(NC=C2CCNC(C)=O)C=C1	27.2%
4	Approved; Nutraceutical	SmallMoleculeDrug	DB00142	Glutamic Acid	N[C@@H](CCC(O)=O)C(O)=O	26.9%
5	Approved; Investigational	SmallMoleculeDrug	DB01248	Docetaxel	[H][C@@]12C[C@H](O)[C@@]3(C)C(=O)[C@H](O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C5=CC=CC=C5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C1=CC=CC=C1	25.6%
6	Approved	SmallMoleculeDrug	DB01744	Camphor	[H][C@@]12CC[C@@](C)(C(=O)C1)C2(C)C	25.5%
7	Approved; Investigational	BiotechDrug	DB00015	Reteplase	NA	25.4%
8	Approved; Vet approved	SmallMoleculeDrug	DB08818	Hyaluronic acid	CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@@H]1O[C@@H]([C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)[C@H]2NC(C)=O)[C@H](O)[C@H]1O)C(O)=O	25.1%
9	Approved	SmallMoleculeDrug	DB11157	Anthralin	OC1=CC=CC2=C1C(=O)C1=C(O)C=CC=C1C2	24.1%
10	Experimental	SmallMoleculeDrug	DB02621	Latrunculin A	[H]\C1=C(\[H])/C(/[H])=C([H])\[C@@]([H])(C)CC[C@]2([H])C[C@]([H])(C[C@@](O)(O2)[C@]2([H])CSC(O)=N2)OC(=O)\C([H])=C(C)/CC1	24.1%
11	Experimental	SmallMoleculeDrug	DB02890	6-Hydroxyuridine-5'-Phosphate	[H][C@]1(COP(O)(O)=O)O[C@@]([H])(N2C(O)=CC(O)=NC2=O)[C@]([H])(O)[C@]1([H])O	23.3%
12	Approved	SmallMoleculeDrug	DB13269	Dichlorobenzyl alcohol	OCC1=C(Cl)C=C(Cl)C=C1	23.1%
13	Approved; Investigational	SmallMoleculeDrug	DB11638	Artenimol	[H][C@@]1(C)CC[C@@]2([H])[C@@]([H])(C)C([H])(O)O[C@]3([H])O[C@@]4(C)CC[C@]1([H])[C@@]23OO4	23.0%
14	Approved	SmallMoleculeDrug	DB01050	Ibuprofen	CC(C)CC1=CC=C(C=C1)C(C)C(O)=O	22.4%
15	Approved	BiotechDrug	DB06404	Human C1-esterase inhibitor	NA	22.0%
16	Approved; Investigational; Withdrawn	BiotechDrug	DB00013	Urokinase	NA	21.6%
17	Approved	SmallMoleculeDrug	DB00184	Nicotine	CN1CCC[C@H]1C1=CN=CC=C1	21.4%
18	Approved; Vet approved	SmallMoleculeDrug	DB01229	Paclitaxel	[H][C@]12[C@H](OC(=O)C3=CC=CC=C3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)C4=CC=CC=C4)C4=CC=CC=C4)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C	21.3%
19	Approved; Investigational	SmallMoleculeDrug	DB01136	Carvedilol	COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=CC=CC=C1N2	21.1%
20	Approved	SmallMoleculeDrug	DB00514	Dextromethorphan	[H][C@]12CC3=C(C=C(OC)C=C3)[C@@]3(CCCC[C@]13[H])CCN2C	21.0%