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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P08913
No. Gene UniProt ID Protein Name Pathway PDB
1 ADRA2A P08913 Alpha-2A adrenergic receptor hsa04022; hsa04080 1HLL; 1HO9; 1HOD; 1HOF


96 known interactions (drugs) of input target (ADRA2A): Alpha-2A adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB06678 Esmirtazapine Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB01018 Guanfacine Thumb
3 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
4 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
6 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB00935 Oxymetazoline Thumb
9 Approved SmallMoleculeDrug DB11124 Racepinephrine Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB09242 Moxonidine Thumb
11 Approved SmallMoleculeDrug DB00800 Fenoldopam Thumb
12 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
14 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB09205 Moxisylyte Thumb
16 Experimental;
Illicit		 SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
18 Approved;
Nutraceutical;
Withdrawn		 SmallMoleculeDrug DB01363 Ephedra Thumb
19 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
20 Vet approved SmallMoleculeDrug DB11477 Xylazine Thumb
21 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
22 Approved;
Investigational		 SmallMoleculeDrug DB04846 Celiprolol Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB00656 Trazodone Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB06623 Flupirtine Thumb
25 Approved SmallMoleculeDrug DB00692 Phentolamine Thumb
26 Approved SmallMoleculeDrug DB09244 Pirlindole Thumb
27 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb
28 Approved;
Illicit		 SmallMoleculeDrug DB00865 Benzphetamine Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb
30 Approved;
Investigational		 SmallMoleculeDrug DB00320 Dihydroergotamine Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
32 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
33 Approved SmallMoleculeDrug DB00457 Prazosin Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB01608 Propericiazine Thumb
35 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb
36 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb
37 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb
38 Approved SmallMoleculeDrug DB06707 Levonordefrin Thumb
39 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
40 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb
41 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
42 Approved SmallMoleculeDrug DB06711 Naphazoline Thumb
43 Approved SmallMoleculeDrug DB00925 Phenoxybenzamine Thumb
44 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
45 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
46 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
47 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb
48 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb
49 Approved;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB00397 Phenylpropanolamine Thumb
50 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
51 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb
52 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
53 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb
54 Approved SmallMoleculeDrug DB01365 Mephentermine Thumb
55 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb
56 Approved SmallMoleculeDrug DB00964 Apraclonidine Thumb
57 Approved SmallMoleculeDrug DB00968 Methyldopa Thumb
58 Approved SmallMoleculeDrug DB09195 Lorpiprazole Thumb
59 Experimental SmallMoleculeDrug DB09202 Cirazoline Thumb
60 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
61 Approved SmallMoleculeDrug DB00575 Clonidine Thumb
62 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
63 Approved SmallMoleculeDrug DB00217 Bethanidine Thumb
64 Approved;
Investigational		 SmallMoleculeDrug DB00697 Tizanidine Thumb
65 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
66 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb
67 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
68 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb
69 Approved;
Investigational		 SmallMoleculeDrug DB11738 Rilmenidine Thumb
70 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
71 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
72 Approved;
Vet approved		 SmallMoleculeDrug DB00668 Epinephrine Thumb
73 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
74 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
75 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb
76 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
77 Approved;
Investigational		 SmallMoleculeDrug DB06694 Xylometazoline Thumb
78 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
79 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb
80 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
81 Approved;
Investigational		 SmallMoleculeDrug DB00629 Guanabenz Thumb
82 Approved SmallMoleculeDrug DB00484 Brimonidine Thumb
83 Approved;
Vet approved		 SmallMoleculeDrug DB00797 Tolazoline Thumb
84 Approved;
Vet approved		 SmallMoleculeDrug DB00633 Dexmedetomidine Thumb
85 Approved SmallMoleculeDrug DB00449 Dipivefrin Thumb
86 Approved SmallMoleculeDrug DB11577 Indigotindisulfonic Acid Thumb
87 Approved;
Investigational		 SmallMoleculeDrug DB01136 Carvedilol Thumb
88 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
89 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
90 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
91 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
92 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
93 Approved;
Illicit		 SmallMoleculeDrug DB01577 Methamphetamine Thumb
94 Approved SmallMoleculeDrug DB11278 DL-Methylephedrine Thumb
95 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
96 Approved;
Investigational		 SmallMoleculeDrug DB06262 Droxidopa Thumb


20 predicted interactions (drugs) of input target (ADRA2A): Alpha-2A adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb 91.6%
2 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb 88.1%
3 Investigational SmallMoleculeDrug DB05461 OPC-28326 Thumb 86.4%
4 Approved SmallMoleculeDrug DB05271 Rotigotine Thumb 85.6%
5 Approved;
Investigational		 SmallMoleculeDrug DB09128 Brexpiprazole Thumb 85.1%
6 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 82.5%
7 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb 79.6%
8 Approved SmallMoleculeDrug DB00292 Etomidate Thumb 79.0%
9 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb 78.8%
10 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 78.4%
11 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb 78.0%
12 Approved;
Illicit		 SmallMoleculeDrug DB01579 Phendimetrazine Thumb 77.5%
13 Approved;
Illicit		 SmallMoleculeDrug DB01576 Dextroamphetamine Thumb 76.6%
14 Approved;
Vet approved		 SmallMoleculeDrug DB01614 Acepromazine Thumb 76.4%
15 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb 75.8%
16 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 75.4%
17 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb 75.3%
18 Approved SmallMoleculeDrug DB08922 Perospirone Thumb 75.1%
19 Approved SmallMoleculeDrug DB00215 Citalopram Thumb 74.9%
20 Investigational SmallMoleculeDrug DB09204 Arotinolol Thumb 74.5%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.