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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P42262
No. Gene UniProt ID Protein Name Pathway PDB
1 GRIA2 P42262 Glutamate receptor 2 hsa04024; hsa04080; hsa04713; hsa04720; hsa04723; hsa04724; hsa04728; hsa04730; hsa05014; hsa05030; hsa05031; hsa05033 2WJW; 2WJX; 2XHD; 3R7X; 3RN8; 3RNN; 3UA8


42 known interactions (drugs) of input target (GRIA2): Glutamate receptor 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB02999 Quisqualate Thumb
2 Approved;
Illicit		 SmallMoleculeDrug DB01352 Aprobarbital Thumb
3 Experimental SmallMoleculeDrug DB03319 (S)-ATPA Thumb
4 Experimental SmallMoleculeDrug DB04798 THIO-ATPA Thumb
5 Experimental SmallMoleculeDrug DB04129 Willardiine Thumb
6 Approved SmallMoleculeDrug DB01355 Hexobarbital Thumb
7 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb
8 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
9 Experimental SmallMoleculeDrug DB02966 Fluoro-Willardiine Thumb
10 Experimental SmallMoleculeDrug DB01664 (S)-Des-Me-Ampa Thumb
11 Experimental SmallMoleculeDrug DB08305 (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide Thumb
12 Illicit;
Investigational		 SmallMoleculeDrug DB05047 CX717 Thumb
13 Illicit SmallMoleculeDrug DB01483 Barbital Thumb
14 Approved;
Illicit		 SmallMoleculeDrug DB01351 Amobarbital Thumb
15 Investigational SmallMoleculeDrug DB04982 Talampanel Thumb
16 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb
17 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb
18 Experimental SmallMoleculeDrug DB04152 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic Acid Thumb
19 Approved;
Vet approved		 SmallMoleculeDrug DB00794 Primidone Thumb
20 Approved SmallMoleculeDrug DB00849 Methylphenobarbital Thumb
21 Experimental SmallMoleculeDrug DB03240 (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic Acid Thumb
22 Experimental SmallMoleculeDrug DB07455 N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide Thumb
23 Experimental SmallMoleculeDrug DB04599 Aniracetam Thumb
24 Approved SmallMoleculeDrug DB01354 Heptabarbital Thumb
25 Approved SmallMoleculeDrug DB13146 Fluciclovine (18F) Thumb
26 Experimental SmallMoleculeDrug DB07598 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE Thumb
27 Approved SmallMoleculeDrug DB01346 Quinidine barbiturate Thumb
28 Approved;
Vet approved		 SmallMoleculeDrug DB00599 Thiopental Thumb
29 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb
30 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb
31 Experimental;
Illicit		 SmallMoleculeDrug DB01496 Barbituric acid derivative Thumb
32 Experimental SmallMoleculeDrug DB04000 Bromo-Willardiine Thumb
33 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb
34 Experimental SmallMoleculeDrug DB02818 Iodo-Willardiine Thumb
35 Experimental SmallMoleculeDrug DB02057 (S)-AMPA Thumb
36 Experimental SmallMoleculeDrug DB03759 FG-9041 Thumb
37 Experimental SmallMoleculeDrug DB08304 (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide Thumb
38 Approved;
Illicit		 SmallMoleculeDrug DB01353 Butethal Thumb
39 Approved;
Investigational		 SmallMoleculeDrug DB01174 Phenobarbital Thumb
40 Experimental SmallMoleculeDrug DB02347 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid Thumb
41 Experimental SmallMoleculeDrug DB08303 (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide Thumb
42 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb


20 predicted interactions (drugs) of input target (GRIA2): Glutamate receptor 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb 75.8%
2 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 70.0%
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb 66.6%
4 Investigational SmallMoleculeDrug DB05087 Ganaxolone Thumb 59.8%
5 Approved;
Investigational		 SmallMoleculeDrug DB11582 Thiocolchicoside Thumb 58.3%
6 Approved;
Illicit		 SmallMoleculeDrug DB01215 Estazolam Thumb 57.9%
7 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb 57.8%
8 Approved;
Illicit		 SmallMoleculeDrug DB00628 Clorazepate Thumb 57.1%
9 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 57.0%
10 Approved SmallMoleculeDrug DB09118 Stiripentol Thumb 56.2%
11 Experimental SmallMoleculeDrug DB13983 5,7,2′-trihydroxy-6,8-dimethoxyflavone Thumb 56.0%
12 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb 55.4%
13 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB01107 Methyprylon Thumb 55.0%
14 Approved;
Illicit		 SmallMoleculeDrug DB01588 Prazepam Thumb 54.5%
15 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00404 Alprazolam Thumb 54.2%
16 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb 54.1%
17 Approved SmallMoleculeDrug DB00186 Lorazepam Thumb 53.7%
18 Approved SmallMoleculeDrug DB01205 Flumazenil Thumb 53.3%
19 Approved;
Illicit		 SmallMoleculeDrug DB00371 Meprobamate Thumb 53.1%
20 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb 53.0%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.