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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q06432
No. Gene UniProt ID Protein Name Pathway PDB
1 CACNG1 Q06432 Voltage-dependent calcium channel gamma-1 subunit hsa04010; hsa04260; hsa04261; hsa04921; hsa05410; hsa05412; hsa05414 NA


9 known interactions (drugs) of input target (CACNG1): Voltage-dependent calcium channel gamma-1 subunit
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb
2 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB04842 Fluspirilene Thumb
4 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB00343 Diltiazem Thumb
6 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00653 Magnesium sulfate Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB00528 Lercanidipine Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB01054 Nitrendipine Thumb
9 Approved SmallMoleculeDrug DB00898 Ethanol Thumb


20 predicted interactions (drugs) of input target (CACNG1): Voltage-dependent calcium channel gamma-1 subunit
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00996 Gabapentin Thumb 56.7%
2 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 55.0%
3 Approved;
Investigational		 SmallMoleculeDrug DB00270 Isradipine Thumb 53.8%
4 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 52.4%
5 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 51.1%
6 Approved SmallMoleculeDrug DB00825 Menthol Thumb 48.2%
7 Approved;
Investigational		 SmallMoleculeDrug DB09238 Manidipine Thumb 47.7%
8 Approved;
Investigational		 SmallMoleculeDrug DB09232 Cilnidipine Thumb 47.5%
9 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb 46.6%
10 Approved;
Investigational		 SmallMoleculeDrug DB06712 Nilvadipine Thumb 46.5%
11 Approved SmallMoleculeDrug DB00401 Nisoldipine Thumb 46.3%
12 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb 44.3%
13 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb 43.9%
14 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 43.8%
15 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 43.7%
16 Approved;
Investigational		 SmallMoleculeDrug DB09231 Benidipine Thumb 42.2%
17 Approved;
Investigational		 SmallMoleculeDrug DB09235 Efonidipine Thumb 39.7%
18 Approved;
Investigational		 SmallMoleculeDrug DB09236 Lacidipine Thumb 38.7%
19 Approved;
Investigational		 SmallMoleculeDrug DB01023 Felodipine Thumb 38.5%
20 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb 37.8%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.