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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P07949
No. Gene UniProt ID Protein Name Pathway PDB
1 RET P07949 Proto-oncogene tyrosine-protein kinase receptor Ret hsa05200; hsa05216; hsa05230 1XPD; 2IVS; 2IVT; 2IVU; 2IVV; 2X2K; 2X2L; 2X2M; 2X2U; 4CKI; 4CKJ; 4UX8

8 known interactions (drugs) of input target (RET): Proto-oncogene tyrosine-protein kinase receptor Ret
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb
2 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb
3 Experimental SmallMoleculeDrug DB01809 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Thumb
4 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb
5 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
6 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb
7 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb
8 Approved;
SmallMoleculeDrug DB08875 Cabozantinib Thumb

20 predicted interactions (drugs) of input target (RET): Proto-oncogene tyrosine-protein kinase receptor Ret
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 57.9%
2 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 53.6%
3 Approved;
SmallMoleculeDrug DB09078 Lenvatinib Thumb 50.9%
4 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb 50.8%
5 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 47.5%
6 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 46.7%
7 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 45.5%
8 Approved;
SmallMoleculeDrug DB06595 Midostaurin Thumb 44.8%
9 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 40.3%
10 Experimental SmallMoleculeDrug DB01962 Phosphonotyrosine Thumb 39.4%
11 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 38.4%
12 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb 33.9%
13 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb 32.5%
14 Investigational SmallMoleculeDrug DB05984 RAF-265 Thumb 32.3%
15 Approved;
SmallMoleculeDrug DB04868 Nilotinib Thumb 31.8%
16 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 31.5%
17 Investigational SmallMoleculeDrug DB05075 TG-100801 Thumb 29.9%
18 Investigational SmallMoleculeDrug DB05913 OSI-930 Thumb 27.6%
19 Approved;
SmallMoleculeDrug DB06626 Axitinib Thumb 27.6%
20 Investigational BiotechDrug DB06101 IMC-1C11 Thumb 27.1%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.