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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P14416
No. Gene UniProt ID Protein Name Pathway PDB
1 DRD2 P14416 D(2) dopamine receptor hsa04015; hsa04024; hsa04080; hsa04540; hsa04728; hsa05012; hsa05030; hsa05034 1I15; 5AER


111 known interactions (drugs) of input target (DRD2): D(2) dopamine receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB04857 Brasofensine Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB09223 Blonanserin Thumb
3 Approved SmallMoleculeDrug DB01063 Acetophenazine Thumb
4 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
5 Approved SmallMoleculeDrug DB11275 Epicriptine Thumb
6 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB06016 Cariprazine Thumb
9 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
10 Approved SmallMoleculeDrug DB01623 Thiothixene Thumb
11 Approved;
Investigational		 SmallMoleculeDrug DB09097 Quinagolide Thumb
12 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb
13 Approved;
Vet approved		 SmallMoleculeDrug DB00433 Prochlorperazine Thumb
14 Approved SmallMoleculeDrug DB00502 Haloperidol Thumb
15 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb
16 Approved SmallMoleculeDrug DB01235 Levodopa Thumb
17 Experimental SmallMoleculeDrug DB09207 AS-8112 Thumb
18 Investigational SmallMoleculeDrug DB05687 BL-1020 Thumb
19 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
20 Investigational SmallMoleculeDrug DB06477 Sumanirole Thumb
21 Investigational SmallMoleculeDrug DB12579 JNJ-37822681 Thumb
22 Approved;
Investigational		 SmallMoleculeDrug DB04844 Tetrabenazine Thumb
23 Approved;
Withdrawn		 SmallMoleculeDrug DB00409 Remoxipride Thumb
24 Approved SmallMoleculeDrug DB00623 Fluphenazine Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
26 Approved;
Vet approved		 SmallMoleculeDrug DB01614 Acepromazine Thumb
27 Approved;
Investigational		 SmallMoleculeDrug DB00831 Trifluoperazine Thumb
28 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
29 Experimental;
Illicit		 SmallMoleculeDrug DB01549 Rolicyclidine Thumb
30 Approved SmallMoleculeDrug DB01425 Alizapride Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB01233 Metoclopramide Thumb
32 Investigational SmallMoleculeDrug DB12061 Pardoprunox Thumb
33 Approved SmallMoleculeDrug DB01100 Pimozide Thumb
34 Investigational SmallMoleculeDrug DB04924 Itopride Thumb
35 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
36 Approved;
Investigational		 SmallMoleculeDrug DB00490 Buspirone Thumb
37 Approved;
Vet approved		 SmallMoleculeDrug DB00450 Droperidol Thumb
38 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb
39 Approved SmallMoleculeDrug DB00805 Minaprine Thumb
40 Investigational SmallMoleculeDrug DB12093 Tetrahydropalmatine Thumb
41 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb
42 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
43 Approved;
Investigational		 SmallMoleculeDrug DB09128 Brexpiprazole Thumb
44 Investigational SmallMoleculeDrug DB06454 Sarizotan Thumb
45 Approved SmallMoleculeDrug DB08922 Perospirone Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
47 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb
48 Approved;
Investigational		 SmallMoleculeDrug DB01621 Pipotiazine Thumb
49 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
50 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb
51 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
52 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb
53 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
54 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
55 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
56 Approved SmallMoleculeDrug DB05271 Rotigotine Thumb
57 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
58 Approved SmallMoleculeDrug DB00850 Perphenazine Thumb
59 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb
60 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
61 Investigational SmallMoleculeDrug DB04889 Bicifadine Thumb
62 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
63 Withdrawn SmallMoleculeDrug DB00372 Thiethylperazine Thumb
64 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
65 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
66 Approved;
Withdrawn		 SmallMoleculeDrug DB00679 Thioridazine Thumb
67 Approved;
Vet approved		 SmallMoleculeDrug DB00508 Triflupromazine Thumb
68 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb
69 Investigational SmallMoleculeDrug DB04888 Bifeprunox Thumb
70 Investigational SmallMoleculeDrug DB12478 Piribedil Thumb
71 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb
72 Approved;
Investigational		 SmallMoleculeDrug DB01069 Promethazine Thumb
73 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
74 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
75 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
76 Investigational SmallMoleculeDrug DB06077 Lumateperone Thumb
77 Approved;
Investigational		 SmallMoleculeDrug DB09224 Melperone Thumb
78 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb
79 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
80 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb
81 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
82 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
83 Approved;
Investigational		 SmallMoleculeDrug DB05316 Pimavanserin Thumb
84 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
85 Investigational SmallMoleculeDrug DB05766 ACP-104 Thumb
86 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb
87 Approved;
Investigational		 SmallMoleculeDrug DB06288 Amisulpride Thumb
88 Approved;
Investigational		 SmallMoleculeDrug DB00933 Mesoridazine Thumb
89 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb
90 Withdrawn SmallMoleculeDrug DB01038 Carphenazine Thumb
91 Approved;
Investigational		 SmallMoleculeDrug DB04842 Fluspirilene Thumb
92 Approved;
Investigational		 SmallMoleculeDrug DB09018 Bromopride Thumb
93 Approved SmallMoleculeDrug DB00915 Amantadine Thumb
94 Approved;
Investigational		 SmallMoleculeDrug DB01043 Memantine Thumb
95 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01184 Domperidone Thumb
96 Investigational SmallMoleculeDrug DB05964 Amitifadine Thumb
97 Experimental SmallMoleculeDrug DB04599 Aniracetam Thumb
98 Approved SmallMoleculeDrug DB11274 Dihydro-alpha-ergocryptine Thumb
99 Approved SmallMoleculeDrug DB01618 Molindone Thumb
100 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
101 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00875 Flupentixol Thumb
102 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb
103 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
104 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb
105 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
106 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
107 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
108 Investigational SmallMoleculeDrug DB12518 Raclopride Thumb
109 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
110 Approved;
Investigational		 SmallMoleculeDrug DB00391 Sulpiride Thumb
111 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb


20 predicted interactions (drugs) of input target (DRD2): D(2) dopamine receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 85.9%
2 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb 84.6%
3 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb 82.8%
4 Approved SmallMoleculeDrug DB00800 Fenoldopam Thumb 81.5%
5 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb 80.3%
6 Approved;
Investigational		 SmallMoleculeDrug DB01608 Propericiazine Thumb 79.5%
7 Approved;
Investigational		 SmallMoleculeDrug DB04908 Flibanserin Thumb 79.4%
8 Investigational;
Nutraceutical		 SmallMoleculeDrug DB08839 Serotonin Thumb 79.4%
9 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb 79.0%
10 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 78.7%
11 Approved SmallMoleculeDrug DB00215 Citalopram Thumb 78.5%
12 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb 77.0%
13 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb 76.9%
14 Approved;
Investigational		 SmallMoleculeDrug DB09289 Tianeptine Thumb 76.7%
15 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb 76.2%
16 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb 75.8%
17 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb 75.5%
18 Approved SmallMoleculeDrug DB00247 Methysergide Thumb 74.9%
19 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00604 Cisapride Thumb 74.3%
20 Approved;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB00397 Phenylpropanolamine Thumb 73.8%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.