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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P08588
No. Gene UniProt ID Protein Name Pathway PDB
1 ADRB1 P08588 Beta-1 adrenergic receptor hsa04020; hsa04022; hsa04024; hsa04080; hsa04261; hsa04540; hsa04923; hsa04924; hsa04970; hsa05414 2LSQ


74 known interactions (drugs) of input target (ADRB1): Beta-1 adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB01214 Metipranolol Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00571 Propranolol Thumb
3 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
4 Investigational SmallMoleculeDrug DB09204 Arotinolol Thumb
5 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01407 Clenbuterol Thumb
6 Approved SmallMoleculeDrug DB08808 Bupranolol Thumb
7 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
8 Approved SmallMoleculeDrug DB01182 Propafenone Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB01136 Carvedilol Thumb
10 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
11 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb
12 Experimental SmallMoleculeDrug DB03566 Spermidine Thumb
13 Approved SmallMoleculeDrug DB00187 Esmolol Thumb
14 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
15 Experimental SmallMoleculeDrug DB08558 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Thumb
16 Approved;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB00397 Phenylpropanolamine Thumb
17 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB04861 Nebivolol Thumb
19 Approved SmallMoleculeDrug DB01580 Oxprenolol Thumb
20 Approved;
Investigational		 SmallMoleculeDrug DB01359 Penbutolol Thumb
21 Approved;
Investigational		 SmallMoleculeDrug DB01288 Fenoterol Thumb
22 Approved;
Investigational		 SmallMoleculeDrug DB00195 Betaxolol Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB01193 Acebutolol Thumb
24 Experimental SmallMoleculeDrug DB08347 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile Thumb
25 Approved;
Withdrawn		 SmallMoleculeDrug DB00866 Alprenolol Thumb
26 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb
27 Approved SmallMoleculeDrug DB08807 Bopindolol Thumb
28 Approved SmallMoleculeDrug DB01295 Bevantolol Thumb
29 Approved SmallMoleculeDrug DB01365 Mephentermine Thumb
30 Approved;
Nutraceutical		 SmallMoleculeDrug DB00127 Spermine Thumb
31 Approved SmallMoleculeDrug DB01102 Arbutamine Thumb
32 Approved;
Investigational		 SmallMoleculeDrug DB09351 Levobetaxolol Thumb
33 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb
34 Approved SmallMoleculeDrug DB01210 Levobunolol Thumb
35 Approved SmallMoleculeDrug DB00841 Dobutamine Thumb
36 Approved SmallMoleculeDrug DB00489 Sotalol Thumb
37 Experimental;
Investigational		 SmallMoleculeDrug DB06726 Bufuralol Thumb
38 Approved SmallMoleculeDrug DB00521 Carteolol Thumb
39 Experimental SmallMoleculeDrug DB13781 Xamoterol Thumb
40 Approved SmallMoleculeDrug DB00871 Terbutaline Thumb
41 Approved SmallMoleculeDrug DB00612 Bisoprolol Thumb
42 Approved SmallMoleculeDrug DB11124 Racepinephrine Thumb
43 Approved SmallMoleculeDrug DB01203 Nadolol Thumb
44 Approved;
Investigational		 SmallMoleculeDrug DB00960 Pindolol Thumb
45 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
46 Approved SmallMoleculeDrug DB01291 Pirbuterol Thumb
47 Approved;
Investigational		 SmallMoleculeDrug DB04846 Celiprolol Thumb
48 Approved SmallMoleculeDrug DB00335 Atenolol Thumb
49 Approved;
Vet approved		 SmallMoleculeDrug DB01001 Salbutamol Thumb
50 Experimental SmallMoleculeDrug DB01917 Putrescine Thumb
51 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
52 Approved;
Vet approved		 SmallMoleculeDrug DB00668 Epinephrine Thumb
53 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
54 Approved;
Investigational		 SmallMoleculeDrug DB00264 Metoprolol Thumb
55 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
56 Approved SmallMoleculeDrug DB00217 Bethanidine Thumb
57 Approved;
Investigational		 SmallMoleculeDrug DB01064 Isoprenaline Thumb
58 Experimental SmallMoleculeDrug DB09013 Befunolol Thumb
59 Approved;
Investigational		 SmallMoleculeDrug DB00983 Formoterol Thumb
60 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
61 Approved SmallMoleculeDrug DB00938 Salmeterol Thumb
62 Approved SmallMoleculeDrug DB00373 Timolol Thumb
63 Approved SmallMoleculeDrug DB01297 Practolol Thumb
64 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
65 Approved SmallMoleculeDrug DB00598 Labetalol Thumb
66 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
67 Approved;
Nutraceutical;
Withdrawn		 SmallMoleculeDrug DB01363 Ephedra Thumb
68 Approved SmallMoleculeDrug DB11278 DL-Methylephedrine Thumb
69 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
70 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
71 Approved;
Investigational		 SmallMoleculeDrug DB01118 Amiodarone Thumb
72 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
73 Approved;
Investigational		 SmallMoleculeDrug DB06262 Droxidopa Thumb
74 Approved SmallMoleculeDrug DB00221 Isoetarine Thumb


20 predicted interactions (drugs) of input target (ADRB1): Beta-1 adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00925 Phenoxybenzamine Thumb 79.6%
2 Approved SmallMoleculeDrug DB00449 Dipivefrin Thumb 77.8%
3 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 75.1%
4 Approved SmallMoleculeDrug DB00457 Prazosin Thumb 73.6%
5 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 73.5%
6 Approved;
Investigational		 SmallMoleculeDrug DB13139 Levosalbutamol Thumb 73.0%
7 Investigational SmallMoleculeDrug DB12248 Tulobuterol Thumb 73.0%
8 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb 72.3%
9 Approved SmallMoleculeDrug DB09082 Vilanterol Thumb 70.8%
10 Experimental SmallMoleculeDrug DB07543 (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Thumb 69.1%
11 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 69.0%
12 Approved SmallMoleculeDrug DB11577 Indigotindisulfonic Acid Thumb 68.8%
13 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 68.6%
14 Investigational SmallMoleculeDrug DB05849 NCX 950 Thumb 68.5%
15 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb 68.3%
16 Approved;
Investigational		 SmallMoleculeDrug DB09273 Doxofylline Thumb 67.8%
17 Approved SmallMoleculeDrug DB11587 Etafedrine Thumb 67.4%
18 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb 67.3%
19 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 67.0%
20 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb 66.8%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.