QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P30536
No. Gene UniProt ID Protein Name Pathway PDB
1 TSPO P30536 Translocator protein hsa04080; hsa04979; hsa05166 NA


12 known interactions (drugs) of input target (TSPO): Translocator protein
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB00897 Triazolam Thumb
2 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01178 Chlormezanone Thumb
3 Approved;
Illicit		 SmallMoleculeDrug DB00628 Clorazepate Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00231 Temazepam Thumb
5 Approved;
Illicit		 SmallMoleculeDrug DB01544 Flunitrazepam Thumb
6 Approved SmallMoleculeDrug DB01587 Ketazolam Thumb
7 Approved;
Illicit		 SmallMoleculeDrug DB01068 Clonazepam Thumb
8 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00829 Diazepam Thumb
9 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00962 Zaleplon Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB00402 Eszopiclone Thumb
11 Approved SmallMoleculeDrug DB00186 Lorazepam Thumb
12 Approved SmallMoleculeDrug DB01198 Zopiclone Thumb


20 predicted interactions (drugs) of input target (TSPO): Translocator protein
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00842 Oxazepam Thumb 83.8%
2 Approved SmallMoleculeDrug DB01595 Nitrazepam Thumb 79.4%
3 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 79.2%
4 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB00801 Halazepam Thumb 78.3%
5 Approved;
Illicit		 SmallMoleculeDrug DB01589 Quazepam Thumb 77.8%
6 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb 77.7%
7 Approved;
Illicit		 SmallMoleculeDrug DB01567 Fludiazepam Thumb 77.2%
8 Approved;
Illicit		 SmallMoleculeDrug DB00349 Clobazam Thumb 76.4%
9 Approved SmallMoleculeDrug DB09118 Stiripentol Thumb 76.0%
10 Approved SmallMoleculeDrug DB01594 Cinolazepam Thumb 75.2%
11 Approved SmallMoleculeDrug DB00546 Adinazolam Thumb 74.4%
12 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb 74.2%
13 Approved;
Illicit		 SmallMoleculeDrug DB01588 Prazepam Thumb 74.0%
14 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 73.5%
15 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00690 Flurazepam Thumb 73.3%
16 Approved;
Illicit		 SmallMoleculeDrug DB00683 Midazolam Thumb 73.3%
17 Approved;
Illicit		 SmallMoleculeDrug DB01215 Estazolam Thumb 73.2%
18 Approved;
Illicit		 SmallMoleculeDrug DB01559 Clotiazepam Thumb 73.1%
19 Approved;
Illicit		 SmallMoleculeDrug DB01437 Glutethimide Thumb 72.9%
20 Approved SmallMoleculeDrug DB00292 Etomidate Thumb 72.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.