QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q15722
No. Gene UniProt ID Protein Name Pathway PDB
1 LTB4R Q15722 Leukotriene B4 receptor 1 hsa04080 NA


3 known interactions (drugs) of input target (LTB4R): Leukotriene B4 receptor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB06248 Amelubant Thumb
2 Approved SmallMoleculeDrug DB09285 Morniflumate Thumb
3 Investigational SmallMoleculeDrug DB12961 Leukotriene B4 Thumb


20 predicted interactions (drugs) of input target (LTB4R): Leukotriene B4 receptor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 BiotechDrug DB00030 Insulin Human Thumb 22.5%
2 Approved BiotechDrug DB00071 Insulin Pork Thumb 21.6%
3 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 20.4%
4 Approved SmallMoleculeDrug DB06739 Seratrodast Thumb 19.4%
5 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02772 Sucrose Thumb 16.8%
6 Approved SmallMoleculeDrug DB00795 Sulfasalazine Thumb 16.4%
7 Approved;
Nutraceutical		 SmallMoleculeDrug DB00172 L-Proline Thumb 16.0%
8 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb 15.4%
9 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00162 Vitamin A Thumb 14.9%
10 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb 14.9%
11 Approved SmallMoleculeDrug DB01207 Ridogrel Thumb 14.6%
12 Approved;
Investigational		 SmallMoleculeDrug DB00806 Pentoxifylline Thumb 14.4%
13 Experimental SmallMoleculeDrug DB07180 5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide Thumb 14.2%
14 Experimental SmallMoleculeDrug DB02078 Triglyme Thumb 14.0%
15 Approved BiotechDrug DB00031 Tenecteplase Thumb 13.9%
16 Experimental SmallMoleculeDrug DB02860 Calyculin A Thumb 13.8%
17 Approved SmallMoleculeDrug DB00515 Cisplatin Thumb 13.8%
18 Experimental SmallMoleculeDrug DB02169 9,10-Deepithio-9,10-Didehydroacanthifolicin Thumb 13.6%
19 Experimental SmallMoleculeDrug DB04141 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Thumb 13.3%
20 Investigational SmallMoleculeDrug DB05157 KC706 Thumb 13.3%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.