QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P10589
No. Gene UniProt ID Protein Name Pathway PDB
1 NR2F1 P10589 COUP transcription factor 1 NA 2EBL


1 known interactions (drugs) of input target (NR2F1): COUP transcription factor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB06732 beta-Naphthoflavone Thumb


20 predicted interactions (drugs) of input target (NR2F1): COUP transcription factor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00126 Vitamin C Thumb 24.7%
2 Approved;
Experimental		 SmallMoleculeDrug DB07776 Flavone Thumb 21.2%
3 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 19.5%
4 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 16.9%
5 Investigational SmallMoleculeDrug DB04468 Afimoxifene Thumb 16.7%
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB00139 Succinic acid Thumb 15.7%
7 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00174 L-Asparagine Thumb 15.0%
8 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01108 Trilostane Thumb 14.7%
9 Approved SmallMoleculeDrug DB04941 Crofelemer Thumb 14.4%
10 Withdrawn SmallMoleculeDrug DB07931 Hexestrol Thumb 14.4%
11 Approved;
Nutraceutical		 SmallMoleculeDrug DB00160 L-Alanine Thumb 14.4%
12 Investigational SmallMoleculeDrug DB04847 Roxadustat Thumb 14.3%
13 Experimental SmallMoleculeDrug DB03467 Naringenin Thumb 14.2%
14 Approved;
Investigational		 SmallMoleculeDrug DB09213 Dexibuprofen Thumb 14.1%
15 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 13.4%
16 Approved;
Investigational		 SmallMoleculeDrug DB00255 Diethylstilbestrol Thumb 13.2%
17 Approved SmallMoleculeDrug DB11577 Indigotindisulfonic Acid Thumb 13.1%
18 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00119 Pyruvic acid Thumb 13.1%
19 Approved SmallMoleculeDrug DB00286 Conjugated estrogens Thumb 12.7%
20 Investigational;
Withdrawn		 SmallMoleculeDrug DB00197 Troglitazone Thumb 12.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.