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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P35218
No. Gene UniProt ID Protein Name Pathway PDB
1 CA5A P35218 Carbonic anhydrase 5A, mitochondrial hsa00910 NA

4 known interactions (drugs) of input target (CA5A): Carbonic anhydrase 5A, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB01194 Brinzolamide Thumb
2 Approved;
SmallMoleculeDrug DB00909 Zonisamide Thumb
3 Experimental SmallMoleculeDrug DB03385 4-Methylimidazole Thumb
4 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb

20 predicted interactions (drugs) of input target (CA5A): Carbonic anhydrase 5A, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Vet approved
SmallMoleculeDrug DB00819 Acetazolamide Thumb 46.8%
2 Approved;
SmallMoleculeDrug DB01144 Diclofenamide Thumb 42.0%
3 Approved SmallMoleculeDrug DB00562 Benzthiazide Thumb 41.1%
4 Withdrawn SmallMoleculeDrug DB00311 Ethoxzolamide Thumb 39.0%
5 Approved SmallMoleculeDrug DB00606 Cyclothiazide Thumb 38.5%
6 Approved SmallMoleculeDrug DB00703 Methazolamide Thumb 35.6%
7 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 33.6%
8 Approved SmallMoleculeDrug DB09460 Sodium carbonate Thumb 32.4%
9 Approved SmallMoleculeDrug DB00869 Dorzolamide Thumb 32.3%
10 Approved;
SmallMoleculeDrug DB00774 Hydroflumethiazide Thumb 32.1%
11 Approved;
SmallMoleculeDrug DB00482 Celecoxib Thumb 27.7%
12 Experimental SmallMoleculeDrug DB08155 N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE Thumb 26.0%
13 Approved SmallMoleculeDrug DB00436 Bendroflumethiazide Thumb 25.9%
14 Approved;
Vet approved
SmallMoleculeDrug DB00423 Methocarbamol Thumb 24.7%
15 Approved;
Vet approved
SmallMoleculeDrug DB00880 Chlorothiazide Thumb 24.5%
16 Approved;
SmallMoleculeDrug DB05541 Brivaracetam Thumb 24.4%
17 Investigational SmallMoleculeDrug DB12418 Saccharin Thumb 23.9%
18 Experimental SmallMoleculeDrug DB08156 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID Thumb 23.9%
19 Approved SmallMoleculeDrug DB13269 Dichlorobenzyl alcohol Thumb 23.0%
20 Approved;
SmallMoleculeDrug DB01942 Formic Acid Thumb 21.8%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.