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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P84077
No. Gene UniProt ID Protein Name Pathway PDB
1 ARF1 P84077 ADP-ribosylation factor 1 hsa04072; hsa04144; hsa05110; hsa05134 1HUR; 1RE0; 1U81; 3O47; 4HMY


7 known interactions (drugs) of input target (ARF1): ADP-ribosylation factor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB07348 Brefeldin A Thumb
2 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb
3 Experimental SmallMoleculeDrug DB04137 Guanosine-5'-Triphosphate Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB09462 Glycerin Thumb
5 Experimental SmallMoleculeDrug DB04315 Guanosine-5'-Diphosphate Thumb
6 Experimental SmallMoleculeDrug DB02774 1,3-Propandiol Thumb
7 Experimental SmallMoleculeDrug DB04121 Guanosine-3'-Monophosphate-5'-Diphosphate Thumb


20 predicted interactions (drugs) of input target (ARF1): ADP-ribosylation factor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 31.3%
2 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 31.1%
3 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 26.5%
4 Investigational SmallMoleculeDrug DB11693 Voclosporin Thumb 26.4%
5 Experimental SmallMoleculeDrug DB02482 Phosphonothreonine Thumb 23.8%
6 Approved;
Experimental		 SmallMoleculeDrug DB03796 Palmitic Acid Thumb 22.1%
7 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 22.0%
8 Experimental SmallMoleculeDrug DB04105 N-Heptylformamide Thumb 21.9%
9 Experimental SmallMoleculeDrug DB01864 5'-Guanosine-Diphosphate-Monothiophosphate Thumb 20.8%
10 Approved;
Vet approved		 SmallMoleculeDrug DB00281 Lidocaine Thumb 20.5%
11 Approved SmallMoleculeDrug DB00515 Cisplatin Thumb 20.5%
12 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb 19.5%
13 Investigational SmallMoleculeDrug DB05157 KC706 Thumb 19.1%
14 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb 19.1%
15 Investigational SmallMoleculeDrug DB05969 SNS-032 Thumb 18.8%
16 Approved SmallMoleculeDrug DB00973 Ezetimibe Thumb 18.7%
17 Approved SmallMoleculeDrug DB03754 Tromethamine Thumb 18.6%
18 Experimental SmallMoleculeDrug DB08740 CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE Thumb 18.2%
19 Withdrawn SmallMoleculeDrug DB04825 Prenylamine Thumb 18.1%
20 Approved SmallMoleculeDrug DB01595 Nitrazepam Thumb 18.0%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.