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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

2 known interactions (drugs) of input target (MAPK11): Mitogen-activated protein kinase 11
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb
2 Investigational SmallMoleculeDrug DB05157 KC706 Thumb

20 predicted interactions (drugs) of input target (MAPK11): Mitogen-activated protein kinase 11
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 63.0%
2 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb 35.0%
3 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 31.2%
4 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 30.0%
5 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb 29.5%
6 Approved;
SmallMoleculeDrug DB09078 Lenvatinib Thumb 28.2%
7 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 27.9%
8 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 27.0%
9 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 25.1%
10 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 25.0%
11 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 25.0%
12 Investigational SmallMoleculeDrug DB05913 OSI-930 Thumb 24.4%
13 Investigational SmallMoleculeDrug DB04879 Vatalanib Thumb 22.7%
14 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 22.1%
15 Investigational SmallMoleculeDrug DB05075 TG-100801 Thumb 21.9%
16 Approved;
Vet approved
SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 21.0%
17 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 20.0%
18 Experimental SmallMoleculeDrug DB02482 Phosphonothreonine Thumb 19.9%
19 Investigational BiotechDrug DB06101 IMC-1C11 Thumb 19.5%
20 Experimental SmallMoleculeDrug DB01962 Phosphonotyrosine Thumb 19.5%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.