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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P05230
No. Gene UniProt ID Protein Name Pathway PDB
1 FGF1 P05230 Fibroblast growth factor 1 hsa04010; hsa04014; hsa04015; hsa04151; hsa04390; hsa04810; hsa05200; hsa05218; hsa05224; hsa05226

12 known interactions (drugs) of input target (FGF1): Fibroblast growth factor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB01901 Sucrosofate Thumb
2 Experimental SmallMoleculeDrug DB08238 5-AMINO-NAPHTALENE-2-MONOSULFONATE Thumb
3 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb
4 Approved SmallMoleculeDrug DB00686 Pentosan Polysulfate Thumb
5 Experimental SmallMoleculeDrug DB04409 Naphthalene Trisulfonate Thumb
6 Approved;
SmallMoleculeDrug DB01942 Formic Acid Thumb
7 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb
8 Approved;
SmallMoleculeDrug DB01109 Heparin Thumb
9 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb
10 Experimental SmallMoleculeDrug DB02264 O2-Sulfo-Glucuronic Acid Thumb
11 Approved;
SmallMoleculeDrug DB01025 Amlexanox Thumb
12 Experimental SmallMoleculeDrug DB03959 N,O6-Disulfo-Glucosamine Thumb

20 predicted interactions (drugs) of input target (FGF1): Fibroblast growth factor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 36.0%
2 Investigational SmallMoleculeDrug DB12307 Foretinib Thumb 34.2%
3 Investigational SmallMoleculeDrug DB05434 ABT-510 Thumb 33.7%
4 Approved;
SmallMoleculeDrug DB09221 Polaprezinc Thumb 30.7%
5 Experimental SmallMoleculeDrug DB02491 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine Thumb 29.4%
6 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 27.4%
7 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 26.5%
8 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 26.0%
9 Approved;
SmallMoleculeDrug DB09078 Lenvatinib Thumb 25.0%
10 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb 25.0%
11 Approved;
SmallMoleculeDrug DB08912 Dabrafenib Thumb 24.8%
12 Experimental SmallMoleculeDrug DB04522 Dexfosfoserine Thumb 24.4%
13 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb 24.4%
14 Approved;
SmallMoleculeDrug DB06595 Midostaurin Thumb 24.3%
15 Approved;
BiotechDrug DB00075 Muromonab Thumb 24.1%
16 Approved;
BiotechDrug DB00070 Hyaluronidase Thumb 23.8%
17 Experimental SmallMoleculeDrug DB02058 SU4984 Thumb 23.2%
18 Experimental SmallMoleculeDrug DB03981 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Thumb 22.8%
19 Approved;
BiotechDrug DB06205 Hyaluronidase (Human Recombinant) Thumb 22.5%
20 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 22.2%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.