QuartataWeb 1.0

12 known interactions (drugs) of input target (FGF1): Fibroblast growth factor 1

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter
1	Experimental	SmallMoleculeDrug	DB01901	Sucrosofate	OS(=O)(=O)OC[C@H]1O[C@@](COS(O)(=O)=O)(O[C@H]2O[C@H](COS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]2OS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@@H]1OS(O)(=O)=O
2	Experimental	SmallMoleculeDrug	DB08238	5-AMINO-NAPHTALENE-2-MONOSULFONATE	NC1=CC=CC2=CC(=CC=C12)S(O)(=O)=O
3	Approved	BiotechDrug	DB10772	Foreskin keratinocyte (neonatal)	NA
4	Approved	SmallMoleculeDrug	DB00686	Pentosan Polysulfate	O[C@@H]1CO[C@@H](O[C@@H]2CO[C@@H](O)[C@H](OS(O)(=O)=O)[C@H]2OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O
5	Experimental	SmallMoleculeDrug	DB04409	Naphthalene Trisulfonate	[O-]S(=O)(=O)C1=CC2=C(C=C1)C(=CC(=C2)S([O-])(=O)=O)S([O-])(=O)=O
6	Approved; Experimental; Investigational	SmallMoleculeDrug	DB01942	Formic Acid	OC=O
7	Approved	SmallMoleculeDrug	DB06589	Pazopanib	CN(C1=CC2=NN(C)C(C)=C2C=C1)C1=CC=NC(NC2=CC=C(C)C(=C2)S(N)(=O)=O)=N1
8	Approved; Investigational	SmallMoleculeDrug	DB01109	Heparin	NA
9	Approved	BiotechDrug	DB10770	Foreskin fibroblast (neonatal)	NA
10	Experimental	SmallMoleculeDrug	DB02264	O2-Sulfo-Glucuronic Acid	[H][C@@]1(O)O[C@@]([H])(C(O)=O)[C@@]([H])(O)[C@]([H])(O)[C@@]1([H])OS(O)(=O)=O
11	Approved; Investigational	SmallMoleculeDrug	DB01025	Amlexanox	CC(C)C1=CC2=C(OC3=NC(N)=C(C=C3C2=O)C(O)=O)C=C1
12	Experimental	SmallMoleculeDrug	DB03959	N,O6-Disulfo-Glucosamine	[H][C@]1(O)O[C@]([H])(COS(O)(=O)=O)[C@@]([H])(O)[C@]([H])(O)[C@@]1([H])NS(O)(=O)=O

20 predicted interactions (drugs) of input target (FGF1): Fibroblast growth factor 1

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Approved; Investigational	SmallMoleculeDrug	DB12010	Fostamatinib	COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP(O)(O)=O)C=C3)=N2)=CC(OC)=C1OC	36.0%
2	Investigational	SmallMoleculeDrug	DB12307	Foretinib	COC1=C(OCCCN2CCOCC2)C=C2N=CC=C(OC3=C(F)C=C(C=C3)N=C(O)C3(CC3)C(=O)NC3=CC=C(F)C=C3)C2=C1	34.2%
3	Investigational	SmallMoleculeDrug	DB05434	ABT-510	CCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)CN(C)C(C)=O)C(C)C)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC	33.7%
4	Approved; Investigational	SmallMoleculeDrug	DB09221	Polaprezinc	[Zn++].[H][C@@](CC1=CN=CN1)([N-]C(=O)CCN)C([O-])=O	30.7%
5	Experimental	SmallMoleculeDrug	DB02491	4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine	CC(C)(N)C1=CC=C(C=C1)C1=NC(NC2=CC=C(CCN3CCOCC3)C=C2)=NC=C1Cl	29.4%
6	Approved	SmallMoleculeDrug	DB08896	Regorafenib	CNC(=O)C1=CC(OC2=CC(F)=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)=CC=N1	27.4%
7	Approved	SmallMoleculeDrug	DB09079	Nintedanib	COC(=O)C1=CC2=C(C=C1)\C(=C(\NC1=CC=C(C=C1)N(C)C(=O)CN1CCN(C)CC1)C1=CC=CC=C1)C(O)=N2	26.5%
8	Investigational	SmallMoleculeDrug	DB05014	XL999	NA	26.0%
9	Approved; Investigational	SmallMoleculeDrug	DB09078	Lenvatinib	COC1=C(C=C2C(OC3=CC(Cl)=C(NC(O)=NC4CC4)C=C3)=CC=NC2=C1)C(O)=N	25.0%
10	Approved; Investigational	SmallMoleculeDrug	DB01268	Sunitinib	CCN(CC)CCNC(=O)C1=C(C)NC(\C=C2/C(=O)NC3=C2C=C(F)C=C3)=C1C	25.0%
11	Approved; Investigational	SmallMoleculeDrug	DB08912	Dabrafenib	CC(C)(C)C1=NC(=C(S1)C1=NC(N)=NC=C1)C1=C(F)C(NS(=O)(=O)C2=C(F)C=CC=C2F)=CC=C1	24.8%
12	Experimental	SmallMoleculeDrug	DB04522	Dexfosfoserine	N[C@@H](COP(O)(O)=O)C(O)=O	24.4%
13	Approved; Investigational	SmallMoleculeDrug	DB00398	Sorafenib	CNC(=O)C1=NC=CC(OC2=CC=C(NC(=O)NC3=CC(=C(Cl)C=C3)C(F)(F)F)C=C2)=C1	24.4%
14	Approved; Investigational	SmallMoleculeDrug	DB06595	Midostaurin	CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)N1C3=C(C=CC=C3)C3=C1C1=C(C4=C(C=CC=C4)N21)C1=C3CNC1=O)N(C)C(=O)C1=CC=CC=C1	24.3%
15	Approved; Investigational	BiotechDrug	DB00075	Muromonab	NA	24.1%
16	Approved; Investigational	BiotechDrug	DB00070	Hyaluronidase	NA	23.8%
17	Experimental	SmallMoleculeDrug	DB02058	SU4984	OC1=NC2=CC=CC=C2C1CC1=CC=C(C=C1)N1CCN(CC1)C=O	23.2%
18	Experimental	SmallMoleculeDrug	DB03981	1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid	[H][C@@]1(O)OC(=C[C@]([H])(O)[C@@]1([H])OS(O)(=O)=O)C(O)=O	22.8%
19	Approved; Investigational	BiotechDrug	DB06205	Hyaluronidase (Human Recombinant)	NA	22.5%
20	Investigational	SmallMoleculeDrug	DB06080	ABT-869	NA	22.2%