QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P15259
No. Gene UniProt ID Protein Name Pathway PDB
1 PGAM2 P15259 Phosphoglycerate mutase 2 hsa00010; hsa00260; hsa01100; hsa01200; hsa01230; hsa04922; hsa05230 NA


2 known interactions (drugs) of input target (PGAM2): Phosphoglycerate mutase 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB01681 Benzene Hexacarboxylic Acid Thumb
2 Experimental SmallMoleculeDrug DB04510 3-phospho-D-glyceric acid Thumb


20 predicted interactions (drugs) of input target (PGAM2): Phosphoglycerate mutase 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00139 Succinic acid Thumb 19.7%
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB00126 Vitamin C Thumb 18.3%
3 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 18.3%
4 Experimental SmallMoleculeDrug DB03026 Phosphoglycolohydroxamic Acid Thumb 18.2%
5 Investigational SmallMoleculeDrug DB12340 Navitoclax Thumb 16.8%
6 Experimental SmallMoleculeDrug DB02726 2-Phosphoglycolic Acid Thumb 16.7%
7 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb 16.5%
8 Approved SmallMoleculeDrug DB01197 Captopril Thumb 16.3%
9 Investigational;
Withdrawn		 SmallMoleculeDrug DB00197 Troglitazone Thumb 16.2%
10 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 16.1%
11 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 16.0%
12 Experimental;
Investigational		 SmallMoleculeDrug DB03366 Imidazole Thumb 15.2%
13 Approved;
Vet approved		 SmallMoleculeDrug DB00626 Bacitracin Thumb 14.8%
14 Experimental SmallMoleculeDrug DB03909 Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Thumb 14.7%
15 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb 14.1%
16 Investigational SmallMoleculeDrug DB08382 Gosogliptin Thumb 14.1%
17 Investigational SmallMoleculeDrug DB05452 PH-284 Thumb 13.9%
18 Approved;
Nutraceutical		 SmallMoleculeDrug DB01373 Calcium Thumb 13.9%
19 Experimental SmallMoleculeDrug DB03314 Fluorotryptophane Thumb 13.8%
20 Approved;
Investigational		 SmallMoleculeDrug DB00642 Pemetrexed Thumb 13.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.