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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q15842
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNJ8 Q15842 ATP-sensitive inward rectifier potassium channel 8 hsa04022 NA

8 known interactions (drugs) of input target (KCNJ8): ATP-sensitive inward rectifier potassium channel 8
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Investigational SmallMoleculeDrug DB01289 Glisoxepide Thumb
2 Approved;
SmallMoleculeDrug DB11148 Butamben Thumb
3 Approved;
SmallMoleculeDrug DB01251 Gliquidone Thumb
4 Approved;
SmallMoleculeDrug DB00914 Phenformin Thumb
5 Approved;
Vet approved
SmallMoleculeDrug DB01392 Yohimbine Thumb
6 Approved;
SmallMoleculeDrug DB00922 Levosimendan Thumb
7 Approved;
Vet approved
SmallMoleculeDrug DB01154 Thiamylal Thumb
8 Approved SmallMoleculeDrug DB01016 Glyburide Thumb

20 predicted interactions (drugs) of input target (KCNJ8): ATP-sensitive inward rectifier potassium channel 8
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00222 Glimepiride Thumb 39.0%
2 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 37.2%
3 Approved;
SmallMoleculeDrug DB00839 Tolazamide Thumb 36.5%
4 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 31.7%
5 Approved SmallMoleculeDrug DB01119 Diazoxide Thumb 31.5%
6 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 31.0%
7 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 27.5%
8 Approved;
SmallMoleculeDrug DB00142 Glutamic Acid Thumb 27.2%
9 Approved;
SmallMoleculeDrug DB09061 Cannabidiol Thumb 27.0%
10 Approved;
SmallMoleculeDrug DB11633 Isavuconazole Thumb 25.4%
11 Approved;
SmallMoleculeDrug DB01244 Bepridil Thumb 24.6%
12 Approved SmallMoleculeDrug DB00217 Bethanidine Thumb 24.4%
13 Approved;
SmallMoleculeDrug DB05389 Tetrachlorodecaoxide Thumb 23.6%
14 Experimental;
BiotechDrug DB14009 Medical Cannabis Thumb 23.2%
15 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb 23.2%
16 Approved;
SmallMoleculeDrug DB01382 Glycodiazine Thumb 22.3%
17 Approved;
SmallMoleculeDrug DB00204 Dofetilide Thumb 21.9%
18 Approved;
SmallMoleculeDrug DB01074 Perhexiline Thumb 21.6%
19 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 21.6%
20 Approved;
SmallMoleculeDrug DB09238 Manidipine Thumb 21.5%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.