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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P01024
No. Gene UniProt ID Protein Name Pathway PDB
1 C3 P01024 Complement C3 hsa04145; hsa04610; hsa05133; hsa05134; hsa05140; hsa05142; hsa05150; hsa05152; hsa05167; hsa05168; hsa05203; hsa05322


5 known interactions (drugs) of input target (C3): Complement C3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational
SmallMoleculeDrug DB01593 Zinc Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB09130 Copper Thumb
3 Experimental SmallMoleculeDrug DB01915 S-Hydroxycysteine Thumb
4 Approved;
Investigational
BiotechDrug DB00028 Immune Globulin Human Thumb
5 Investigational BiotechDrug DB06492 Mirococept Thumb


20 predicted interactions (drugs) of input target (C3): Complement C3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Nutraceutical
SmallMoleculeDrug DB00142 Glutamic Acid Thumb 32.4%
2 Approved BiotechDrug DB00054 Abciximab Thumb 25.5%
3 Approved;
Investigational
BiotechDrug DB01257 Eculizumab Thumb 23.9%
4 Approved;
Investigational
BiotechDrug DB00075 Muromonab Thumb 23.9%
5 Approved;
Investigational
BiotechDrug DB00056 Gemtuzumab ozogamicin Thumb 22.3%
6 Approved;
Investigational
BiotechDrug DB00095 Efalizumab Thumb 20.1%
7 Approved BiotechDrug DB00098 Antithymocyte immunoglobulin (rabbit) Thumb 20.1%
8 Approved;
Nutraceutical;
Vet approved
SmallMoleculeDrug DB00145 Glycine Thumb 20.0%
9 Approved;
Investigational
BiotechDrug DB00072 Trastuzumab Thumb 20.0%
10 Investigational;
Withdrawn
BiotechDrug DB00111 Daclizumab Thumb 19.5%
11 Approved BiotechDrug DB00002 Cetuximab Thumb 19.2%
12 Approved SmallMoleculeDrug DB11093 Calcium Citrate Thumb 19.2%
13 Experimental SmallMoleculeDrug DB03814 2-(N-Morpholino)-Ethanesulfonic Acid Thumb 19.1%
14 Approved;
Investigational
BiotechDrug DB00078 Ibritumomab tiuxetan Thumb 19.1%
15 Approved;
Experimental
SmallMoleculeDrug DB03796 Palmitic Acid Thumb 18.5%
16 Approved;
Investigational
BiotechDrug DB00005 Etanercept Thumb 17.7%
17 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB00141 N-Acetylglucosamine Thumb 17.7%
18 Approved;
Investigational
BiotechDrug DB06372 Rilonacept Thumb 17.3%
19 Approved;
Investigational
BiotechDrug DB00074 Basiliximab Thumb 17.1%
20 Approved;
Investigational
BiotechDrug DB11767 Sarilumab Thumb 17.0%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.