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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O00264
No. Gene UniProt ID Protein Name Pathway PDB
1 PGRMC1 O00264 Membrane-associated progesterone receptor component 1 NA NA

3 known interactions (drugs) of input target (PGRMC1): Membrane-associated progesterone receptor component 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB01104 Sertraline Thumb
2 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb
3 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb

20 predicted interactions (drugs) of input target (PGRMC1): Membrane-associated progesterone receptor component 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 52.1%
2 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 45.4%
3 Approved SmallMoleculeDrug DB00408 Loxapine Thumb 43.6%
4 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 43.6%
5 Approved;
SmallMoleculeDrug DB00907 Cocaine Thumb 43.3%
6 Approved;
SmallMoleculeDrug DB00555 Lamotrigine Thumb 42.7%
7 Approved;
SmallMoleculeDrug DB01151 Desipramine Thumb 41.3%
8 Approved;
SmallMoleculeDrug DB06148 Mianserin Thumb 39.0%
9 Approved;
Vet approved
SmallMoleculeDrug DB00721 Procaine Thumb 38.8%
10 Approved;
SmallMoleculeDrug DB00193 Tramadol Thumb 38.8%
11 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 38.7%
12 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 37.9%
13 Approved;
SmallMoleculeDrug DB01142 Doxepin Thumb 37.5%
14 Approved;
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 37.2%
15 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 36.8%
16 Approved;
SmallMoleculeDrug DB00934 Maprotiline Thumb 36.3%
17 Approved;
SmallMoleculeDrug DB00334 Olanzapine Thumb 36.3%
18 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb 36.1%
19 Approved;
SmallMoleculeDrug DB00182 Amphetamine Thumb 36.1%
20 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 35.7%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.