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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P26439
No. Gene UniProt ID Protein Name Pathway PDB
1 HSD3B2 P26439 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 hsa00140; hsa01100; hsa04913; hsa04925; hsa04927; hsa04934 NA


2 known interactions (drugs) of input target (HSD3B2): 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb
2 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01108 Trilostane Thumb


20 predicted interactions (drugs) of input target (HSD3B2): 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb 33.1%
2 Approved;
Vet approved		 SmallMoleculeDrug DB00741 Hydrocortisone Thumb 22.0%
3 Experimental SmallMoleculeDrug DB04315 Guanosine-5'-Diphosphate Thumb 21.4%
4 Experimental;
Illicit		 SmallMoleculeDrug DB01536 Androstenedione Thumb 20.4%
5 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 19.9%
6 Approved;
Investigational		 SmallMoleculeDrug DB00255 Diethylstilbestrol Thumb 18.7%
7 Approved SmallMoleculeDrug DB03147 Flavin adenine dinucleotide Thumb 16.6%
8 Experimental SmallMoleculeDrug DB03467 Naringenin Thumb 16.3%
9 Experimental SmallMoleculeDrug DB04141 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Thumb 15.8%
10 Approved;
Withdrawn		 SmallMoleculeDrug DB09092 Xanthinol Thumb 15.0%
11 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb 14.1%
12 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 13.9%
13 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb 13.9%
14 Experimental SmallMoleculeDrug DB06732 beta-Naphthoflavone Thumb 13.7%
15 Approved;
Experimental		 SmallMoleculeDrug DB03017 Lauric Acid Thumb 13.1%
16 Experimental SmallMoleculeDrug DB08020 (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL Thumb 12.9%
17 Investigational SmallMoleculeDrug DB11781 Tosedostat Thumb 12.8%
18 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb 12.7%
19 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB01065 Melatonin Thumb 12.6%
20 Approved;
Vet approved		 SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 12.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.