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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P41143
No. Gene UniProt ID Protein Name Pathway PDB
1 OPRD1 P41143 Delta-type opioid receptor hsa04022; hsa04071; hsa04080 1OZC; 2IQM; 4N6H; 4RWA; 4RWD


44 known interactions (drugs) of input target (OPRD1): Delta-type opioid receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00497 Oxycodone Thumb
2 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb
3 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
4 Approved;
Illicit		 SmallMoleculeDrug DB00318 Codeine Thumb
5 Approved SmallMoleculeDrug DB00836 Loperamide Thumb
6 Investigational SmallMoleculeDrug DB14146 Loxicodegol Thumb
7 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB01452 Heroin Thumb
8 Approved SmallMoleculeDrug DB00854 Levorphanol Thumb
9 Approved;
Illicit		 SmallMoleculeDrug DB09209 Pholcodine Thumb
10 Approved;
Illicit		 SmallMoleculeDrug DB11130 Opium Thumb
11 Illicit;
Vet approved		 SmallMoleculeDrug DB01548 Diprenorphine Thumb
12 Experimental;
Illicit		 SmallMoleculeDrug DB01439 3-Methylthiofentanyl Thumb
13 Approved;
Illicit		 SmallMoleculeDrug DB01081 Diphenoxylate Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB06738 Ketobemidone Thumb
15 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb
16 Approved SmallMoleculeDrug DB00333 Methadone Thumb
17 Illicit;
Vet approved		 SmallMoleculeDrug DB01497 Etorphine Thumb
18 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
19 Experimental;
Illicit		 SmallMoleculeDrug DB01565 Dihydromorphine Thumb
20 Experimental;
Illicit		 SmallMoleculeDrug DB01444 Dimethylthiambutene Thumb
21 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00704 Naltrexone Thumb
22 Approved;
Investigational		 SmallMoleculeDrug DB09272 Eluxadoline Thumb
23 Illicit SmallMoleculeDrug DB01571 3-Methylfentanyl Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB00295 Morphine Thumb
26 Approved;
Illicit		 SmallMoleculeDrug DB00327 Hydromorphone Thumb
27 Approved;
Investigational		 SmallMoleculeDrug DB00708 Sufentanil Thumb
28 Approved;
Illicit		 SmallMoleculeDrug DB00956 Hydrocodone Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb
30 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01192 Oxymorphone Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb
32 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00921 Buprenorphine Thumb
33 Approved;
Illicit;
Vet approved		 SmallMoleculeDrug DB00611 Butorphanol Thumb
34 Approved;
Vet approved		 SmallMoleculeDrug DB01183 Naloxone Thumb
35 Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB01535 Carfentanil Thumb
36 Investigational SmallMoleculeDrug DB05050 ADL5859 Thumb
37 Approved;
Investigational		 SmallMoleculeDrug DB06274 Alvimopan Thumb
38 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06230 Nalmefene Thumb
39 Approved SmallMoleculeDrug DB00844 Nalbuphine Thumb
40 Approved SmallMoleculeDrug DB00899 Remifentanil Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB11691 Naldemedine Thumb
42 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00813 Fentanyl Thumb
43 Approved SmallMoleculeDrug DB06204 Tapentadol Thumb
44 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00647 Dextropropoxyphene Thumb


20 predicted interactions (drugs) of input target (OPRD1): Delta-type opioid receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Vet approved		 SmallMoleculeDrug DB00652 Pentazocine Thumb 79.5%
2 Investigational SmallMoleculeDrug DB05046 V1003 Thumb 78.8%
3 Approved SmallMoleculeDrug DB06800 Methylnaltrexone Thumb 78.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB01209 Dezocine Thumb 75.3%
5 Approved SmallMoleculeDrug DB00454 Pethidine Thumb 71.9%
6 Approved SmallMoleculeDrug DB09049 Naloxegol Thumb 71.7%
7 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 71.6%
8 Investigational SmallMoleculeDrug DB05509 LI-301 Thumb 69.5%
9 Approved;
Investigational		 SmallMoleculeDrug DB11186 Pentoxyverine Thumb 68.8%
10 Approved;
Illicit		 SmallMoleculeDrug DB01433 Methadyl Acetate Thumb 68.7%
11 Approved SmallMoleculeDrug DB00904 Ondansetron Thumb 68.4%
12 Approved;
Illicit		 SmallMoleculeDrug DB01466 Ethylmorphine Thumb 67.7%
13 Approved;
Illicit		 SmallMoleculeDrug DB00913 Anileridine Thumb 67.3%
14 Approved;
Investigational		 SmallMoleculeDrug DB01227 Levomethadyl Acetate Thumb 66.4%
15 Approved;
Investigational		 SmallMoleculeDrug DB09289 Tianeptine Thumb 66.1%
16 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 65.8%
17 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb 65.6%
18 Approved SmallMoleculeDrug DB00504 Levallorphan Thumb 64.7%
19 Investigational SmallMoleculeDrug DB05443 ADL 10-0101 Thumb 61.9%
20 Approved;
Illicit		 SmallMoleculeDrug DB00802 Alfentanil Thumb 61.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.