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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P13631
No. Gene UniProt ID Protein Name Pathway PDB
1 RARG P13631 Retinoic acid receptor gamma NA 1EXA; 1EXX; 1FCX; 1FCY; 1FCZ; 1FD0; 2LBD; 3LBD; 4LBD


15 known interactions (drugs) of input target (RARG): Retinoic acid receptor gamma
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB02741 CD564 Thumb
2 Experimental SmallMoleculeDrug DB07031 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid Thumb
3 Withdrawn SmallMoleculeDrug DB00926 Etretinate Thumb
4 Experimental SmallMoleculeDrug DB03279 Dodecyl-Alpha-D-Maltoside Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB00523 Alitretinoin Thumb
6 Experimental SmallMoleculeDrug DB07294 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid Thumb
7 Investigational SmallMoleculeDrug DB05467 R667 Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB00799 Tazarotene Thumb
9 Investigational SmallMoleculeDrug DB05785 LGD-1550 Thumb
10 Experimental SmallMoleculeDrug DB02258 SR11254 Thumb
11 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb
12 Approved SmallMoleculeDrug DB00210 Adapalene Thumb
13 Experimental SmallMoleculeDrug DB02466 4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid Thumb
14 Experimental SmallMoleculeDrug DB03466 BMS184394 Thumb
15 Approved SmallMoleculeDrug DB00459 Acitretin Thumb


20 predicted interactions (drugs) of input target (RARG): Retinoic acid receptor gamma
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB04942 Tamibarotene Thumb 43.6%
2 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 35.0%
3 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00162 Vitamin A Thumb 33.3%
4 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB04272 Citric Acid Thumb 33.0%
5 Experimental SmallMoleculeDrug DB02877 Arotinoid acid Thumb 32.5%
6 Approved;
Investigational		 SmallMoleculeDrug DB00307 Bexarotene Thumb 32.0%
7 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb 29.2%
8 Approved SmallMoleculeDrug DB00982 Isotretinoin Thumb 27.8%
9 Approved;
Investigational		 SmallMoleculeDrug DB01017 Minocycline Thumb 26.5%
10 Approved SmallMoleculeDrug DB00570 Vinblastine Thumb 26.0%
11 Experimental SmallMoleculeDrug DB01941 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid Thumb 25.4%
12 Approved;
Investigational		 SmallMoleculeDrug DB03756 Doconexent Thumb 24.9%
13 Approved;
Investigational		 SmallMoleculeDrug DB00412 Rosiglitazone Thumb 23.1%
14 Experimental SmallMoleculeDrug DB02379 Beta-D-Glucose Thumb 22.5%
15 Approved;
Investigational		 SmallMoleculeDrug DB00284 Acarbose Thumb 21.8%
16 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 21.7%
17 Approved;
Investigational		 SmallMoleculeDrug DB01393 Bezafibrate Thumb 21.6%
18 Approved;
Investigational		 SmallMoleculeDrug DB02325 Isopropyl Alcohol Thumb 21.4%
19 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 21.2%
20 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb 21.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.