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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P04629
No. Gene UniProt ID Protein Name Pathway PDB
1 NTRK1 P04629 High affinity nerve growth factor receptor hsa04010; hsa04014; hsa04151; hsa04210; hsa04722; hsa04750; hsa05200; hsa05202; hsa05216; hsa05230 1HE7; 1SHC; 1WWA; 1WWW; 2IFG; 4AOJ; 4CRP; 4F0I; 4GT5; 4PMM; 4PMP; 4PMS; 4PMT; 4YNE; 4YPS


4 known interactions (drugs) of input target (NTRK1): High affinity nerve growth factor receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB12010 Fostamatinib Thumb
3 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
4 Approved SmallMoleculeDrug DB00619 Imatinib Thumb


20 predicted interactions (drugs) of input target (NTRK1): High affinity nerve growth factor receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Investigational
SmallMoleculeDrug DB00398 Sorafenib Thumb 46.0%
2 Approved;
Investigational
SmallMoleculeDrug DB08901 Ponatinib Thumb 45.6%
3 Approved;
Investigational
SmallMoleculeDrug DB01254 Dasatinib Thumb 35.0%
4 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 34.9%
5 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 34.9%
6 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 34.5%
7 Approved;
Investigational
SmallMoleculeDrug DB01268 Sunitinib Thumb 33.5%
8 Approved;
Investigational
SmallMoleculeDrug DB06595 Midostaurin Thumb 31.6%
9 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 29.7%
10 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 28.5%
11 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 27.8%
12 Approved;
Investigational
SmallMoleculeDrug DB12267 Brigatinib Thumb 26.5%
13 Approved;
Investigational
SmallMoleculeDrug DB09078 Lenvatinib Thumb 26.5%
14 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb 25.1%
15 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 24.7%
16 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 23.5%
17 Approved;
Investigational
SmallMoleculeDrug DB08912 Dabrafenib Thumb 23.4%
18 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb 23.2%
19 Approved;
Investigational
SmallMoleculeDrug DB01403 Methotrimeprazine Thumb 23.2%
20 Investigational SmallMoleculeDrug DB05913 OSI-930 Thumb 22.9%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.