QuartataWeb 1.0

13 known interactions (drugs) of input target (IL6): Interleukin-6

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter
1	Approved; Investigational	SmallMoleculeDrug	DB09221	Polaprezinc	[Zn++].[H][C@@](CC1=CN=CN1)([N-]C(=O)CCN)C([O-])=O
2	Approved	BiotechDrug	DB10772	Foreskin keratinocyte (neonatal)	NA
3	Approved; Investigational	SmallMoleculeDrug	DB11967	Binimetinib	CN1C=NC2=C(F)C(NC3=CC=C(Br)C=C3F)=C(C=C12)C(=O)NOCCO
4	Investigational	SmallMoleculeDrug	DB05017	YSIL6	NA
5	Investigational	SmallMoleculeDrug	DB06083	Tapinarof	CC(C)C1=C(O)C=C(\C=C\C2=CC=CC=C2)C=C1O
6	Approved; Investigational	BiotechDrug	DB09036	Siltuximab	NA
7	Investigational	SmallMoleculeDrug	DB05767	Andrographolide	[H]\C(C[C@]1([H])C(=C)CC[C@]2([H])[C@](C)(CO)[C@]([H])(O)CC[C@@]12C)=C1/C(=O)OC[C@@]1([H])O
8	Investigational	SmallMoleculeDrug	DB05513	Atiprimod	CCCC1(CCC)CCC2(CCN(CCCN(CC)CC)C2)CC1
9	Investigational	SmallMoleculeDrug	DB12140	Dilmapimod	CC1=CC(F)=CC=C1C1=C2C=CC(=O)N(C2=NC(NC(CO)CO)=N1)C1=C(F)C=CC=C1F
10	Approved	BiotechDrug	DB10770	Foreskin fibroblast (neonatal)	NA
11	Investigational	SmallMoleculeDrug	DB05744	CRx-139	NA
12	Approved; Investigational; Nutraceutical	SmallMoleculeDrug	DB01404	Ginseng	NA
13	Investigational	SmallMoleculeDrug	DB05470	VX-702	NC(=O)N(C1=CC=C(C(N)=O)C(=N1)C1=CC=C(F)C=C1F)C1=C(F)C=CC=C1F

20 predicted interactions (drugs) of input target (IL6): Interleukin-6

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Investigational	SmallMoleculeDrug	DB05412	Talmapimod	[H][C@]1(C)CN(C(=O)C2=C(Cl)C=C3N(C)C=C(C(=O)C(=O)N(C)C)C3=C2)[C@]([H])(C)CN1CC1=CC=C(F)C=C1	50.9%
2	Approved; Investigational	SmallMoleculeDrug	DB01296	Glucosamine	N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O	41.1%
3	Approved; Investigational	SmallMoleculeDrug	DB05676	Apremilast	[H][C@](CS(C)(=O)=O)(N1C(=O)C2=C(C1=O)C(=CC=C2)N=C(C)O)C1=CC(OCC)=C(OC)C=C1	41.1%
4	Investigational	SmallMoleculeDrug	DB05992	Plinabulin	CC(C)(C)C1=C(\C=C2/NC(=O)\C(NC2=O)=C\C2=CC=CC=C2)N=CN1	39.2%
5	Approved; Investigational	SmallMoleculeDrug	DB01593	Zinc	[Zn]	38.4%
6	Investigational	BiotechDrug	DB05758	CYT007-TNFQb	NA	38.2%
7	Approved; Investigational	SmallMoleculeDrug	DB01411	Pranlukast	O=C(NC1=C2OC(=CC(=O)C2=CC=C1)C1=NNN=N1)C1=CC=C(OCCCCC2=CC=CC=C2)C=C1	37.4%
8	Approved	SmallMoleculeDrug	DB08910	Pomalidomide	NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O	36.9%
9	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB01407	Clenbuterol	CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1	35.4%
10	Approved	BiotechDrug	DB08904	Certolizumab pegol	NA	34.9%
11	Investigational	SmallMoleculeDrug	DB05869	Ethyl pyruvate	CCOC(=O)C(C)=O	34.3%
12	Investigational	BiotechDrug	DB04956	Afelimomab	NA	33.1%
13	Investigational	BiotechDrug	DB05879	AME-527	NA	33.0%
14	Investigational	SmallMoleculeDrug	DB05968	PR-104	CS(=O)(=O)OCCN(CCBr)C1=C(C=C(C=C1[N+]([O-])=O)[N+]([O-])=O)C(=O)NCCOP(O)(O)=O	33.0%
15	Investigational	BiotechDrug	DB06495	Onercept	NA	32.6%
16	Investigational	SmallMoleculeDrug	DB05207	SD118	NA	32.2%
17	Approved; Investigational; Withdrawn	SmallMoleculeDrug	DB01041	Thalidomide	O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC=CC=C12	32.1%
18	Approved	SmallMoleculeDrug	DB01427	Amrinone	NC1=CC(=CNC1=O)C1=CC=NC=C1	31.6%
19	Investigational	SmallMoleculeDrug	DB06444	Dexanabinol	CCCCCCC(C)(C)C1=CC(O)=C2[C@H]3CC(CO)=CC[C@@H]3C(C)(C)OC2=C1	31.2%
20	Approved	BiotechDrug	DB00065	Infliximab	NA	30.2%