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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: STITCH; Query type: chemical; # of requested predictions: ; Secondary interactions: no
Input drug 1: 69094686
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter

13 known interactions (drugs) of input target (IL6): Interleukin-6
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB09221 Polaprezinc Thumb
2 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb
3 Approved;
SmallMoleculeDrug DB11967 Binimetinib Thumb
4 Investigational SmallMoleculeDrug DB05017 YSIL6 Thumb
5 Investigational SmallMoleculeDrug DB06083 Tapinarof Thumb
6 Approved;
BiotechDrug DB09036 Siltuximab Thumb
7 Investigational SmallMoleculeDrug DB05767 Andrographolide Thumb
8 Investigational SmallMoleculeDrug DB05513 Atiprimod Thumb
9 Investigational SmallMoleculeDrug DB12140 Dilmapimod Thumb
10 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb
11 Investigational SmallMoleculeDrug DB05744 CRx-139 Thumb
12 Approved;
SmallMoleculeDrug DB01404 Ginseng Thumb
13 Investigational SmallMoleculeDrug DB05470 VX-702 Thumb

20 predicted interactions (drugs) of input target (IL6): Interleukin-6
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Investigational SmallMoleculeDrug DB05412 Talmapimod Thumb 50.9%
2 Approved;
SmallMoleculeDrug DB01296 Glucosamine Thumb 41.1%
3 Approved;
SmallMoleculeDrug DB05676 Apremilast Thumb 41.1%
4 Investigational SmallMoleculeDrug DB05992 Plinabulin Thumb 39.2%
5 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 38.4%
6 Investigational BiotechDrug DB05758 CYT007-TNFQb Thumb 38.2%
7 Approved;
SmallMoleculeDrug DB01411 Pranlukast Thumb 37.4%
8 Approved SmallMoleculeDrug DB08910 Pomalidomide Thumb 36.9%
9 Approved;
Vet approved
SmallMoleculeDrug DB01407 Clenbuterol Thumb 35.4%
10 Approved BiotechDrug DB08904 Certolizumab pegol Thumb 34.9%
11 Investigational SmallMoleculeDrug DB05869 Ethyl pyruvate Thumb 34.3%
12 Investigational BiotechDrug DB04956 Afelimomab Thumb 33.1%
13 Investigational BiotechDrug DB05879 AME-527 Thumb 33.0%
14 Investigational SmallMoleculeDrug DB05968 PR-104 Thumb 33.0%
15 Investigational BiotechDrug DB06495 Onercept Thumb 32.6%
16 Investigational SmallMoleculeDrug DB05207 SD118 Thumb 32.2%
17 Approved;
SmallMoleculeDrug DB01041 Thalidomide Thumb 32.1%
18 Approved SmallMoleculeDrug DB01427 Amrinone Thumb 31.6%
19 Investigational SmallMoleculeDrug DB06444 Dexanabinol Thumb 31.2%
20 Approved BiotechDrug DB00065 Infliximab Thumb 30.2%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.