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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P80365
No. Gene UniProt ID Protein Name Pathway PDB
1 HSD11B2 P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 hsa00140; hsa04960 NA


4 known interactions (drugs) of input target (HSD11B2): Corticosteroid 11-beta-dehydrogenase isozyme 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb
2 Approved;
Illicit		 SmallMoleculeDrug DB01185 Fluoxymesterone Thumb
3 Experimental;
Illicit		 SmallMoleculeDrug DB01569 Formebolone Thumb
4 Approved;
Vet approved		 SmallMoleculeDrug DB00741 Hydrocortisone Thumb


20 predicted interactions (drugs) of input target (HSD11B2): Corticosteroid 11-beta-dehydrogenase isozyme 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 25.8%
2 Approved SmallMoleculeDrug DB00288 Amcinonide Thumb 23.8%
3 Approved;
Withdrawn		 SmallMoleculeDrug DB09092 Xanthinol Thumb 23.2%
4 Nutraceutical SmallMoleculeDrug DB13191 Phosphocreatine Thumb 22.0%
5 Approved SmallMoleculeDrug DB00648 Mitotane Thumb 21.1%
6 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01234 Dexamethasone Thumb 20.9%
7 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00148 Creatine Thumb 20.6%
8 Experimental SmallMoleculeDrug DB04447 1,4-Dithiothreitol Thumb 19.5%
9 Approved;
Vet approved		 SmallMoleculeDrug DB00396 Progesterone Thumb 18.8%
10 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 18.3%
11 Experimental SmallMoleculeDrug DB02930 Adenosine 5'-[γ-thio]triphosphate Thumb 17.3%
12 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb 16.7%
13 Approved BiotechDrug DB00071 Insulin Pork Thumb 16.4%
14 Approved;
Investigational		 SmallMoleculeDrug DB08604 Triclosan Thumb 16.4%
15 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb 16.0%
16 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 16.0%
17 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb 15.9%
18 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB01942 Formic Acid Thumb 15.7%
19 Experimental SmallMoleculeDrug DB04709 (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE Thumb 15.4%
20 Experimental SmallMoleculeDrug DB07958 (2-CARBAMOYLMETHYL-5-PROPYL-OCTAHYDRO-INDOL-7-YL)ACETIC ACID Thumb 15.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.