QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9UEW3
No. Gene UniProt ID Protein Name Pathway PDB
1 MARCO Q9UEW3 Macrophage receptor MARCO hsa04145 NA


2 known interactions (drugs) of input target (MARCO): Macrophage receptor MARCO
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB11132 Silicon dioxide Thumb
2 Approved SmallMoleculeDrug DB09536 Titanium dioxide Thumb


20 predicted interactions (drugs) of input target (MARCO): Macrophage receptor MARCO
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB02659 Cholic Acid Thumb 23.8%
2 Approved SmallMoleculeDrug DB00201 Caffeine Thumb 19.0%
3 Approved;
Investigational		 SmallMoleculeDrug DB01109 Heparin Thumb 17.4%
4 Approved;
Investigational		 SmallMoleculeDrug DB00509 Dextrothyroxine Thumb 16.9%
5 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb 16.0%
6 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00144 Phosphatidyl serine Thumb 15.4%
7 Approved SmallMoleculeDrug DB00364 Sucralfate Thumb 15.2%
8 Experimental SmallMoleculeDrug DB03127 Benzamidine Thumb 14.4%
9 Experimental SmallMoleculeDrug DB01812 Adenosine-3'-5'-Diphosphate Thumb 13.7%
10 Approved;
Investigational		 SmallMoleculeDrug DB00877 Sirolimus Thumb 13.7%
11 Approved SmallMoleculeDrug DB00459 Acitretin Thumb 13.6%
12 Approved;
Investigational		 SmallMoleculeDrug DB06789 Hydroxyprogesterone caproate Thumb 13.6%
13 Investigational SmallMoleculeDrug DB05434 ABT-510 Thumb 13.4%
14 Approved;
Investigational		 SmallMoleculeDrug DB06196 Icatibant Thumb 13.1%
15 Approved;
Investigational		 SmallMoleculeDrug DB01088 Iloprost Thumb 13.0%
16 Approved SmallMoleculeDrug DB00973 Ezetimibe Thumb 12.5%
17 Experimental SmallMoleculeDrug DB07676 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one Thumb 12.4%
18 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb 12.3%
19 Experimental SmallMoleculeDrug DB03935 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid Thumb 12.3%
20 Investigational SmallMoleculeDrug DB05107 16-Bromoepiandrosterone Thumb 12.1%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.