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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: STITCH; Query type: chemical; # of requested predictions: ; Secondary interactions: no
Input drug 1: 649706
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1
Thumb


5 known interactions (drugs) of input target (EPOR): Erythropoietin receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB07637 Dibromotyrosine Thumb
2 Approved BiotechDrug DB09107 Methoxy polyethylene glycol-epoetin beta Thumb
3 Approved;
Investigational		 BiotechDrug DB00012 Darbepoetin alfa Thumb
4 Approved;
Investigational		 BiotechDrug DB08894 Peginesatide Thumb
5 Approved BiotechDrug DB00016 Erythropoietin Thumb


20 predicted interactions (drugs) of input target (EPOR): Erythropoietin receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB01694 D-tartaric acid Thumb 23.9%
2 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 21.1%
3 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB01942 Formic Acid Thumb 20.9%
4 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00091 Cyclosporine Thumb 19.0%
5 Approved;
Investigational		 SmallMoleculeDrug DB02325 Isopropyl Alcohol Thumb 18.9%
6 Approved;
Investigational		 SmallMoleculeDrug DB00242 Cladribine Thumb 18.5%
7 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 18.0%
8 Experimental SmallMoleculeDrug DB02452 Thymidine-5'-Triphosphate Thumb 17.6%
9 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 16.4%
10 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01234 Dexamethasone Thumb 16.3%
11 Investigational BiotechDrug DB06245 Lanoteplase Thumb 15.8%
12 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB14002 D-alpha-Tocopherol acetate Thumb 15.5%
13 Approved;
Investigational		 SmallMoleculeDrug DB08862 Cholecystokinin Thumb 15.5%
14 Approved SmallMoleculeDrug DB09552 Thonzonium Thumb 15.4%
15 Experimental SmallMoleculeDrug DB03945 N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium Thumb 15.2%
16 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb 15.1%
17 Investigational SmallMoleculeDrug DB05479 CZEN 002 Thumb 15.1%
18 Approved;
Investigational		 BiotechDrug DB00113 Technetium Tc-99m arcitumomab Thumb 15.1%
19 Experimental SmallMoleculeDrug DB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Thumb 14.3%
20 Experimental;
Investigational		 SmallMoleculeDrug DB08855 Leukotriene C4 Thumb 14.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.