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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q96P88
No. Gene UniProt ID Protein Name Pathway PDB
1 GNRHR2 Q96P88 Putative gonadotropin-releasing hormone II receptor NA NA


3 known interactions (drugs) of input target (GNRHR2): Putative gonadotropin-releasing hormone II receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00644 Gonadorelin Thumb
2 Approved SmallMoleculeDrug DB00666 Nafarelin Thumb
3 Approved SmallMoleculeDrug DB01406 Danazol Thumb


20 predicted interactions (drugs) of input target (GNRHR2): Putative gonadotropin-releasing hormone II receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Investigational SmallMoleculeDrug DB06494 Sufugolix Thumb 25.7%
2 Approved;
Investigational		 BiotechDrug DB00007 Leuprolide Thumb 24.9%
3 Investigational SmallMoleculeDrug DB05624 Teverelix Thumb 23.9%
4 Approved SmallMoleculeDrug DB06699 Degarelix Thumb 23.7%
5 ;
Luteinizing hormone-releasing factor (pig), 6-D-tryptophan;
pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2		 SmallMoleculeDrug DB06825 Triptorelin Thumb 22.6%
6 Approved SmallMoleculeDrug DB00014 Goserelin Thumb 22.6%
7 Approved;
Investigational		 BiotechDrug DB06719 Buserelin Thumb 21.5%
8 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00106 Abarelix Thumb 21.3%
9 Approved SmallMoleculeDrug DB11619 Gestrinone Thumb 20.9%
10 Approved;
Investigational		 SmallMoleculeDrug DB11979 Elagolix Thumb 19.2%
11 ;
histrelina;
histreline;
histrelinum;
L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-Nim-benzyl-histidyl-L-leucyl-L-arginyl-L-proline ethylamide		 SmallMoleculeDrug DB06788 Histrelin Thumb 18.4%
12 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB04272 Citric Acid Thumb 18.1%
13 Approved SmallMoleculeDrug DB06785 Ganirelix Thumb 18.0%
14 Experimental;
Investigational		 SmallMoleculeDrug DB03010 Patupilone Thumb 16.9%
15 Approved;
Nutraceutical		 SmallMoleculeDrug DB00132 Alpha-Linolenic Acid Thumb 16.7%
16 Approved;
Investigational		 SmallMoleculeDrug DB00050 Cetrorelix Thumb 15.5%
17 Approved;
Vet approved		 SmallMoleculeDrug DB00396 Progesterone Thumb 15.3%
18 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb 15.2%
19 Investigational BiotechDrug DB04988 IGN311 Thumb 14.8%
20 Approved;
Investigational		 SmallMoleculeDrug DB09568 Omega-3-carboxylic acids Thumb 14.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.