QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: STITCH; Query type: chemical; # of requested predictions: ; Secondary interactions: no
Input drug 1: 60198530
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1
Thumb


7 known interactions (drugs) of input target (FGFR3): Fibroblast growth factor receptor 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved BiotechDrug DB00039 Palifermin Thumb
2 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
4 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB08901 Ponatinib Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB09078 Lenvatinib Thumb
7 Investigational SmallMoleculeDrug DB05014 XL999 Thumb


20 predicted interactions (drugs) of input target (FGFR3): Fibroblast growth factor receptor 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 63.7%
2 Approved;
Investigational		 SmallMoleculeDrug DB00398 Sorafenib Thumb 61.7%
3 Approved;
Investigational		 SmallMoleculeDrug DB01268 Sunitinib Thumb 51.2%
4 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 48.1%
5 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 47.6%
6 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb 47.4%
7 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 44.7%
8 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 41.4%
9 Approved;
Investigational		 SmallMoleculeDrug DB06595 Midostaurin Thumb 40.9%
10 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 39.5%
11 Experimental SmallMoleculeDrug DB02058 SU4984 Thumb 39.4%
12 Investigational BiotechDrug DB06101 IMC-1C11 Thumb 37.1%
13 Investigational SmallMoleculeDrug DB04879 Vatalanib Thumb 36.3%
14 Approved;
Investigational		 SmallMoleculeDrug DB06626 Axitinib Thumb 36.0%
15 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 34.9%
16 Investigational SmallMoleculeDrug DB05913 OSI-930 Thumb 34.9%
17 Approved;
Investigational		 SmallMoleculeDrug DB01109 Heparin Thumb 32.7%
18 Approved;
Investigational		 SmallMoleculeDrug DB12267 Brigatinib Thumb 32.0%
19 Approved;
Investigational		 SmallMoleculeDrug DB08875 Cabozantinib Thumb 31.6%
20 Investigational SmallMoleculeDrug DB05075 TG-100801 Thumb 31.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.