QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: STITCH; Query type: chemical; # of requested predictions: ; Secondary interactions: no
Input drug 1: 58204974
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1
Thumb


2 known interactions (drugs) of input target (CLCNKA): Chloride channel protein ClC-Ka
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB04552 Niflumic Acid Thumb
2 Approved SmallMoleculeDrug DB09295 Talniflumate Thumb


20 predicted interactions (drugs) of input target (CLCNKA): Chloride channel protein ClC-Ka
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00482 Celecoxib Thumb 21.8%
2 Experimental SmallMoleculeDrug DB02379 Beta-D-Glucose Thumb 20.3%
3 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00143 Glutathione Thumb 18.9%
4 Approved;
Vet approved		 SmallMoleculeDrug DB00788 Naproxen Thumb 17.9%
5 Approved;
Experimental		 SmallMoleculeDrug DB13346 Bufexamac Thumb 17.2%
6 Approved;
Investigational		 SmallMoleculeDrug DB09212 Loxoprofen Thumb 17.0%
7 Approved;
Investigational		 SmallMoleculeDrug DB06217 Vernakalant Thumb 16.9%
8 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB13783 Acemetacin Thumb 16.8%
9 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb 16.5%
10 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01041 Thalidomide Thumb 16.2%
11 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 16.2%
12 Approved SmallMoleculeDrug DB01600 Tiaprofenic acid Thumb 16.0%
13 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb 15.7%
14 Approved;
Withdrawn		 SmallMoleculeDrug DB00870 Suprofen Thumb 15.7%
15 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb 15.2%
16 Approved;
Investigational		 SmallMoleculeDrug DB06802 Nepafenac Thumb 15.1%
17 Approved;
Investigational		 SmallMoleculeDrug DB01106 Levocabastine Thumb 15.0%
18 Approved;
Investigational		 SmallMoleculeDrug DB09288 Propacetamol Thumb 14.9%
19 Approved;
Vet approved		 SmallMoleculeDrug DB00939 Meclofenamic acid Thumb 14.8%
20 Experimental SmallMoleculeDrug DB04695 FARNESYL THIOPYROPHOSPHATE Thumb 14.8%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.