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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

2 known interactions (drugs) of input target (PRKCG): Protein kinase C gamma type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
2 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb

20 predicted interactions (drugs) of input target (PRKCG): Protein kinase C gamma type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 24.2%
2 Approved SmallMoleculeDrug DB05013 Ingenol Mebutate Thumb 23.8%
3 Experimental SmallMoleculeDrug DB03777 Rbt205 Inhibitor Thumb 23.8%
4 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 21.1%
5 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 20.2%
6 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 18.5%
7 Experimental SmallMoleculeDrug DB02482 Phosphonothreonine Thumb 18.2%
8 Investigational SmallMoleculeDrug DB04468 Afimoxifene Thumb 17.5%
9 Approved;
SmallMoleculeDrug DB00255 Diethylstilbestrol Thumb 17.2%
10 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 16.2%
11 Approved;
SmallMoleculeDrug DB06595 Midostaurin Thumb 16.1%
12 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 15.8%
13 Approved;
Vet approved
SmallMoleculeDrug DB00163 Vitamin E Thumb 15.5%
14 Investigational SmallMoleculeDrug DB06486 Enzastaurin Thumb 15.0%
15 Approved;
SmallMoleculeDrug DB02709 Resveratrol Thumb 14.7%
16 Experimental SmallMoleculeDrug DB04376 13-Acetylphorbol Thumb 14.6%
17 Investigational SmallMoleculeDrug DB01645 Genistein Thumb 14.2%
18 Approved;
SmallMoleculeDrug DB08912 Dabrafenib Thumb 14.0%
19 Investigational SmallMoleculeDrug DB06064 KAI-1455 Thumb 13.9%
20 Experimental SmallMoleculeDrug DB06884 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE Thumb 13.7%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.