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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: STITCH; Query type: chemical; # of requested predictions: ; Secondary interactions: no
Input drug 1: 5775
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter

1 known interactions (drugs) of input target (PRKCZ): Protein kinase C zeta type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb

20 predicted interactions (drugs) of input target (PRKCZ): Protein kinase C zeta type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 26.4%
2 Approved SmallMoleculeDrug DB05013 Ingenol Mebutate Thumb 22.0%
3 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 19.9%
4 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 19.8%
5 Experimental SmallMoleculeDrug DB03777 Rbt205 Inhibitor Thumb 16.4%
6 Approved;
SmallMoleculeDrug DB00255 Diethylstilbestrol Thumb 15.4%
7 Approved SmallMoleculeDrug DB00594 Amiloride Thumb 13.4%
8 Investigational SmallMoleculeDrug DB06064 KAI-1455 Thumb 13.3%
9 Approved;
Vet approved
SmallMoleculeDrug DB00163 Vitamin E Thumb 12.9%
10 Investigational SmallMoleculeDrug DB06641 Perifosine Thumb 12.8%
11 Approved;
SmallMoleculeDrug DB00242 Cladribine Thumb 12.5%
12 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 11.9%
13 Approved;
SmallMoleculeDrug DB09535 Octocrylene Thumb 11.8%
14 Experimental SmallMoleculeDrug DB13869 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol Thumb 11.8%
15 Approved;
SmallMoleculeDrug DB01196 Estramustine Thumb 11.7%
16 Approved;
SmallMoleculeDrug DB00637 Astemizole Thumb 11.6%
17 Approved;
SmallMoleculeDrug DB04930 Permethrin Thumb 11.6%
18 Approved;
SmallMoleculeDrug DB00170 Menadione Thumb 11.5%
19 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb 11.4%
20 Approved;
BiotechDrug DB00028 Immune Globulin Human Thumb 11.3%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.