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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P68400
No. Gene UniProt ID Protein Name Pathway PDB
1 CSNK2A1 P68400 Casein kinase II subunit alpha hsa03008; hsa04064; hsa04137; hsa04310; hsa04520; hsa05162; hsa05168; hsa05169


26 known interactions (drugs) of input target (CSNK2A1): Casein kinase II subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental;
Investigational		 SmallMoleculeDrug DB04216 Quercetin Thumb
2 Experimental SmallMoleculeDrug DB04721 N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE Thumb
3 Experimental SmallMoleculeDrug DB08354 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE Thumb
4 Investigational;
Nutraceutical		 SmallMoleculeDrug DB00171 ATP Thumb
5 Investigational SmallMoleculeDrug DB07715 Emodin Thumb
6 Experimental SmallMoleculeDrug DB04720 S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE Thumb
7 Experimental SmallMoleculeDrug DB08360 2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE Thumb
8 Experimental SmallMoleculeDrug DB08338 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one Thumb
9 Experimental SmallMoleculeDrug DB07802 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE Thumb
10 Experimental SmallMoleculeDrug DB08660 1,2,5,8-tetrahydroxyanthracene-9,10-dione Thumb
11 Experimental SmallMoleculeDrug DB03035 1,8-Di-Hydroxy-4-Nitro-Anthraquinone Thumb
12 Experimental SmallMoleculeDrug DB03127 Benzamidine Thumb
13 Experimental SmallMoleculeDrug DB08353 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE Thumb
14 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
16 Experimental SmallMoleculeDrug DB03924 5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone Thumb
17 Experimental SmallMoleculeDrug DB08362 N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE Thumb
18 Experimental SmallMoleculeDrug DB04719 DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE Thumb
19 Experimental SmallMoleculeDrug DB01765 (5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid Thumb
20 Experimental SmallMoleculeDrug DB04462 Tetrabromo-2-Benzotriazole Thumb
21 Experimental SmallMoleculeDrug DB08340 N,N'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE Thumb
22 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb
23 Experimental SmallMoleculeDrug DB02170 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One Thumb
24 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb
25 Experimental SmallMoleculeDrug DB08473 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole Thumb
26 Experimental SmallMoleculeDrug DB08345 4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE Thumb


20 predicted interactions (drugs) of input target (CSNK2A1): Casein kinase II subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 38.1%
2 Investigational SmallMoleculeDrug DB06486 Enzastaurin Thumb 37.1%
3 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 33.2%
4 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 31.7%
5 Approved SmallMoleculeDrug DB00277 Theophylline Thumb 31.1%
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB00126 Vitamin C Thumb 29.7%
7 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00130 L-Glutamine Thumb 29.6%
8 Approved;
Vet approved		 SmallMoleculeDrug DB00252 Phenytoin Thumb 29.4%
9 Experimental;
Investigational		 SmallMoleculeDrug DB03366 Imidazole Thumb 29.1%
10 Experimental SmallMoleculeDrug DB01375 Aluminium monostearate Thumb 27.8%
11 Approved;
Investigational		 SmallMoleculeDrug DB01370 Aluminium Thumb 24.6%
12 Experimental SmallMoleculeDrug DB01863 Inositol 1,3,4,5-Tetrakisphosphate Thumb 24.4%
13 Experimental SmallMoleculeDrug DB07324 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE Thumb 24.3%
14 Experimental SmallMoleculeDrug DB02910 Octanoyl-Coenzyme A Thumb 24.1%
15 Approved;
Investigational		 SmallMoleculeDrug DB00786 Marimastat Thumb 24.1%
16 Experimental SmallMoleculeDrug DB06834 N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide Thumb 23.5%
17 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 23.2%
18 Investigational SmallMoleculeDrug DB12961 Leukotriene B4 Thumb 23.2%
19 Experimental SmallMoleculeDrug DB07546 [1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Thumb 23.1%
20 Approved;
Investigational		 SmallMoleculeDrug DB03247 Flavin mononucleotide Thumb 22.9%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.