QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P06850
No. Gene UniProt ID Protein Name Pathway PDB
1 CRH P06850 Corticoliberin hsa04730; hsa04934; hsa05034 1GOE; 3EHT; 3EHU


3 known interactions (drugs) of input target (CRH): Corticoliberin
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Vet approved		 BiotechDrug DB01285 Corticotropin Thumb
2 Experimental SmallMoleculeDrug DB02952 Alpha-Aminoisobutyric Acid Thumb
3 Experimental SmallMoleculeDrug DB02556 D-Phenylalanine Thumb


20 predicted interactions (drugs) of input target (CRH): Corticoliberin
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 29.3%
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb 26.4%
3 Investigational BiotechDrug DB06245 Lanoteplase Thumb 25.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 23.5%
5 Experimental SmallMoleculeDrug DB03380 L-Tyrosinamide Thumb 23.0%
6 Experimental SmallMoleculeDrug DB02142 Pyridoxamine-5'-Phosphate Thumb 22.8%
7 Approved SmallMoleculeDrug DB01284 Tetracosactide Thumb 20.1%
8 Approved;
Investigational		 SmallMoleculeDrug DB00786 Marimastat Thumb 19.6%
9 Approved BiotechDrug DB09334 Seractide acetate Thumb 17.9%
10 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 17.3%
11 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 16.9%
12 Experimental SmallMoleculeDrug DB04083 N'-Pyridoxyl-Lysine-5'-Monophosphate Thumb 16.8%
13 Approved;
Nutraceutical		 SmallMoleculeDrug DB00129 Ornithine Thumb 16.8%
14 Experimental SmallMoleculeDrug DB04315 Guanosine-5'-Diphosphate Thumb 16.7%
15 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 16.3%
16 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 15.4%
17 Experimental SmallMoleculeDrug DB02821 Canaline Thumb 15.3%
18 Approved;
Nutraceutical		 SmallMoleculeDrug DB00160 L-Alanine Thumb 15.1%
19 Approved SmallMoleculeDrug DB00245 Benzatropine Thumb 14.6%
20 Experimental SmallMoleculeDrug DB04141 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Thumb 14.3%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.