QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q08345
No. Gene UniProt ID Protein Name Pathway PDB
1 DDR1 Q08345 Epithelial discoidin domain-containing receptor 1 NA 3ZOS; 4AG4; 4BKJ; 4CKR; 5BVK; 5BVN; 5BVO; 5BVW


2 known interactions (drugs) of input target (DDR1): Epithelial discoidin domain-containing receptor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
2 Approved SmallMoleculeDrug DB00619 Imatinib Thumb


20 predicted interactions (drugs) of input target (DDR1): Epithelial discoidin domain-containing receptor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 39.6%
2 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb 34.4%
3 Approved;
Investigational		 SmallMoleculeDrug DB08901 Ponatinib Thumb 29.9%
4 Approved;
Investigational		 SmallMoleculeDrug DB00398 Sorafenib Thumb 26.7%
5 Approved;
Investigational		 SmallMoleculeDrug DB01268 Sunitinib Thumb 26.4%
6 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 26.2%
7 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 25.7%
8 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 23.5%
9 Investigational;
Nutraceutical		 SmallMoleculeDrug DB00171 ATP Thumb 23.2%
10 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 22.9%
11 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 22.4%
12 Approved;
Investigational		 SmallMoleculeDrug DB06595 Midostaurin Thumb 20.9%
13 Approved;
Investigational		 SmallMoleculeDrug DB09078 Lenvatinib Thumb 20.8%
14 Approved;
Investigational		 SmallMoleculeDrug DB12267 Brigatinib Thumb 20.8%
15 Approved;
Investigational		 SmallMoleculeDrug DB08912 Dabrafenib Thumb 19.8%
16 Approved;
Investigational		 SmallMoleculeDrug DB04868 Nilotinib Thumb 19.3%
17 Experimental SmallMoleculeDrug DB04522 Dexfosfoserine Thumb 19.1%
18 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 18.8%
19 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 18.7%
20 Approved;
Investigational		 BiotechDrug DB00102 Becaplermin Thumb 18.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.