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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P11021
No. Gene UniProt ID Protein Name Pathway PDB
1 HSPA5 P11021 78 kDa glucose-regulated protein hsa03060; hsa04141; hsa04612; hsa04918; hsa05020 3IUC; 3LDL; 3LDN; 3LDO; 3LDP


5 known interactions (drugs) of input target (HSPA5): 78 kDa glucose-regulated protein
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb
2 Approved BiotechDrug DB13999 Moroctocog alfa Thumb
3 Approved;
Investigational		 BiotechDrug DB13998 Lonoctocog alfa Thumb
4 Approved;
Vet approved		 SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb
5 Approved;
Investigational		 BiotechDrug DB00025 Antihemophilic factor, human recombinant Thumb


20 predicted interactions (drugs) of input target (HSPA5): 78 kDa glucose-regulated protein
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 42.4%
2 Approved BiotechDrug DB00031 Tenecteplase Thumb 36.3%
3 Investigational BiotechDrug DB06245 Lanoteplase Thumb 35.4%
4 Approved;
Investigational		 BiotechDrug DB09329 Antihemophilic Factor (Recombinant), PEGylated Thumb 28.0%
5 Approved BiotechDrug DB13152 Coagulation Factor IX Human Thumb 27.1%
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb 20.8%
7 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 20.6%
8 Approved SmallMoleculeDrug DB11093 Calcium Citrate Thumb 20.6%
9 Approved;
Investigational		 SmallMoleculeDrug DB01169 Arsenic trioxide Thumb 20.5%
10 Investigational SmallMoleculeDrug DB06081 Caplacizumab Thumb 20.2%
11 Approved BiotechDrug DB09108 Simoctocog Alfa Thumb 20.0%
12 Approved;
Investigational		 BiotechDrug DB00100 Coagulation Factor IX (Recombinant) Thumb 19.8%
13 Approved;
Investigational		 BiotechDrug DB09228 Conestat alfa Thumb 19.6%
14 Approved;
Investigational		 SmallMoleculeDrug DB01296 Glucosamine Thumb 19.0%
15 Approved SmallMoleculeDrug DB11348 Calcium Phosphate Thumb 18.8%
16 Approved;
Investigational		 BiotechDrug DB09109 Turoctocog alfa Thumb 18.6%
17 Approved;
Investigational		 BiotechDrug DB00028 Immune Globulin Human Thumb 17.4%
18 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 17.0%
19 Approved BiotechDrug DB06404 Human C1-esterase inhibitor Thumb 16.5%
20 Approved;
Nutraceutical		 SmallMoleculeDrug DB00126 Vitamin C Thumb 16.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.