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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P10721
No. Gene UniProt ID Protein Name Pathway PDB
1 KIT P10721 Mast/stem cell growth factor receptor Kit hsa04010; hsa04014; hsa04015; hsa04072; hsa04151; hsa04640; hsa04916; hsa05200; hsa05221; hsa05224; hsa05230 1PKG; 1QZJ; 1QZK; 1R01; 1T45; 1T46; 2E9W; 2EC8; 2VIF; 3G0E; 3G0F; 4HVS; 4K94; 4K9E; 4PGZ; 4U0I

17 known interactions (drugs) of input target (KIT): Mast/stem cell growth factor receptor Kit
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB01962 Phosphonotyrosine Thumb
2 Approved;
SmallMoleculeDrug DB04868 Nilotinib Thumb
3 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb
4 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb
5 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
6 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb
7 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb
8 Investigational SmallMoleculeDrug DB05913 OSI-930 Thumb
9 Approved;
SmallMoleculeDrug DB06595 Midostaurin Thumb
10 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb
11 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb
12 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb
13 Approved;
BiotechDrug DB09103 Ancestim Thumb
14 Approved;
SmallMoleculeDrug DB09078 Lenvatinib Thumb
15 Investigational SmallMoleculeDrug DB05146 XL820 Thumb
16 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb
17 Approved SmallMoleculeDrug DB00619 Imatinib Thumb

20 predicted interactions (drugs) of input target (KIT): Mast/stem cell growth factor receptor Kit
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 66.9%
2 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 66.0%
3 Investigational BiotechDrug DB06101 IMC-1C11 Thumb 47.1%
4 Approved;
BiotechDrug DB00102 Becaplermin Thumb 46.3%
5 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb 43.9%
6 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb 43.1%
7 Investigational SmallMoleculeDrug DB05075 TG-100801 Thumb 42.3%
8 Investigational SmallMoleculeDrug DB04879 Vatalanib Thumb 41.0%
9 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 37.9%
10 Approved BiotechDrug DB00039 Palifermin Thumb 37.4%
11 Approved;
SmallMoleculeDrug DB06626 Axitinib Thumb 36.8%
12 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 35.9%
13 Experimental SmallMoleculeDrug DB01809 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Thumb 33.8%
14 Approved;
SmallMoleculeDrug DB08875 Cabozantinib Thumb 33.3%
15 Investigational SmallMoleculeDrug DB05932 Denibulin Thumb 32.8%
16 Experimental SmallMoleculeDrug DB02058 SU4984 Thumb 32.3%
17 Investigational SmallMoleculeDrug DB12874 Quizartinib Thumb 32.2%
18 Approved;
BiotechDrug DB06043 Olaratumab Thumb 30.0%
19 Investigational SmallMoleculeDrug DB05465 Tandutinib Thumb 29.3%
20 Investigational SmallMoleculeDrug DB05184 XL228 Thumb 29.3%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.